Abstract

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Original languageEnglish
JournalTwin Research and Human Genetics
ISSN1832-4274
DOIs
Publication statusE-pub ahead of print - 13. Jul 2019

Fingerprint

Smoking
Term Birth
Education
Dizygotic Twins
Weights and Measures
Sample Size
Epidemiologic Studies
Body Mass Index
Databases
Research

Keywords

  • birth size
  • BMI
  • education
  • height
  • heritability
  • international comparisons
  • Twins

Cite this

@article{e13cd53d3e0a48d2b270047bb714f27d,
title = "The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins",
abstract = "The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.",
keywords = "birth size, BMI, education, height, heritability, international comparisons, Twins",
author = "K. Silventoinen and A. Jelenkovic and Y. Yokoyama and R. Sund and M. Sugawara and M. Tanaka and S. Matsumoto and Bogl, {L. H.} and Freitas, {D. L.} and Maia, {J. A.} and Hjelmborg, {J. V.B.} and S. Aaltonen and M. Piirtola and A. Latvala and L. Calais-Ferreira and Oliveira, {V. C.} and Ferreira, {P. H.} and F. Ji and F. Ning and Z. Pang and Ordo{\~n}ana, {J. R.} and S{\'a}nchez-Romera, {J. F.} and L. Colodro-Conde and Burt, {S. A.} and Klump, {K. L.} and Martin, {N. G.} and Medland, {S. E.} and Montgomery, {G. W.} and C. Kandler and McAdams, {T. A.} and Eley, {T. C.} and Gregory, {A. M.} and Saudino, {K. J.} and L. Dubois and M. Boivin and L. Li and K. Christensen and A. Skytthe and Kyvik, {K. O.} and Pedersen, {N. L.} and M. Bjerregaard-Andersen and H. Beck-Nielsen and M. Sodemann and Q. Tan and M. McGue and F. Rasmussen and Franz, {C. E.} and Harris, {J. R.} and Lee, {S. J.} and Sorensen, {T. I.A.} and {The CODATwins Project}",
year = "2019",
month = "7",
day = "13",
doi = "10.1017/thg.2019.35",
language = "English",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Heinemann",

}

The CODATwins Project : The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. / The CODATwins Project.

In: Twin Research and Human Genetics, 13.07.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The CODATwins Project

T2 - The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

AU - Silventoinen, K.

AU - Jelenkovic, A.

AU - Yokoyama, Y.

AU - Sund, R.

AU - Sugawara, M.

AU - Tanaka, M.

AU - Matsumoto, S.

AU - Bogl, L. H.

AU - Freitas, D. L.

AU - Maia, J. A.

AU - Hjelmborg, J. V.B.

AU - Aaltonen, S.

AU - Piirtola, M.

AU - Latvala, A.

AU - Calais-Ferreira, L.

AU - Oliveira, V. C.

AU - Ferreira, P. H.

AU - Ji, F.

AU - Ning, F.

AU - Pang, Z.

AU - Ordoñana, J. R.

AU - Sánchez-Romera, J. F.

AU - Colodro-Conde, L.

AU - Burt, S. A.

AU - Klump, K. L.

AU - Martin, N. G.

AU - Medland, S. E.

AU - Montgomery, G. W.

AU - Kandler, C.

AU - McAdams, T. A.

AU - Eley, T. C.

AU - Gregory, A. M.

AU - Saudino, K. J.

AU - Dubois, L.

AU - Boivin, M.

AU - Li, L.

AU - Christensen, K.

AU - Skytthe, A.

AU - Kyvik, K. O.

AU - Pedersen, N. L.

AU - Bjerregaard-Andersen, M.

AU - Beck-Nielsen, H.

AU - Sodemann, M.

AU - Tan, Q.

AU - McGue, M.

AU - Rasmussen, F.

AU - Franz, C. E.

AU - Harris, J. R.

AU - Lee, S. J.

AU - Sorensen, T. I.A.

AU - The CODATwins Project

PY - 2019/7/13

Y1 - 2019/7/13

N2 - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

AB - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

KW - birth size

KW - BMI

KW - education

KW - height

KW - heritability

KW - international comparisons

KW - Twins

U2 - 10.1017/thg.2019.35

DO - 10.1017/thg.2019.35

M3 - Journal article

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

ER -