The burden of rotavirus disease in Denmark 2009-2010

Thea K Fischer, Christine Rungoe, Claus Sixtus Jensen, Morten Breindahl, Tine Rikke Jørgensen, Jens-Peter Nielsen, Lise Jensen, Michelle Malon, Vagn Brændholt, Niels Fisker, Karsten Hjelt

Research output: Contribution to journalJournal articleResearchpeer-review


BACKGROUND: This study sought to determine the incidence and the burden of severe diarrheal disease in Denmark with emphasis on rotavirus (RV) disease.

METHODS: This study was designed as a national prospective disease surveillance of children <5 years of age hospitalized for acute gastroenteritis in Denmark during March 2009 to April 2010, using rapid RV and adenovirus antigen detection.

RESULTS: A total of 3100 hospitalizations annually among Danish children <5 years of age can be attributed to acute gastroenteritis and 1210 (39%) of these to RV disease. The majority of RV-associated hospitalizations occur among children ≤ 24 months of age (RV-associated hospitalization rate: 7.7/1000 children ≤ 24 months of age and 3.8/1000 children <5 years of age). Although the well-known seasonal pattern of RV was evident with a peak during the spring months of March through April, our active surveillance demonstrated RV-associated hospitalizations throughout the year. Genotyping of a subset of RV-samples demonstrated high frequency of G1 (39%) and G4 (32%). Adenovirus was detected in 350 acute gastroenteritis-associated hospitalizations (11.2%).

CONCLUSION: In conclusion, we present national disease burden data on severe cases of gastroenteritis and specifically RV-associated disease and demonstrate that RV is indeed ubiquitous in the population and can be considered a major health burden among young Danish children.

Original languageEnglish
JournalPediatric Infectious Disease Journal
Issue number7
Pages (from-to)e126-9
Publication statusPublished - Jul 2011


  • Denmark
  • Female
  • Gastroenteritis
  • Hospitalization
  • Humans
  • Incidence
  • Infant
  • Male
  • Rotavirus Infections
  • Seasons


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