The bactericidal action of benzoic acid and sodium acetate on the gram-negative flora of dialysis fluid

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Abstract

Benzoic acid in concentrations from 0.18 per cent and upwards exerted a bactericidal action on the gram-negative flora of dialysis fluid at pH 4.75 in vitro. At a concentration of 0.32 per cent, a reduction of 10(5) was obtained with 24 hours. Sulphonamide resistance did not affect the bactericidal action. The killing effect was hardly more than directly proportional to the concentration of benzoic acid. Increasing inoculum decreased the bactericidal effect. Therefore, benbzoic acid should not be used as an artificial kidney disinfectant when the concentration of microorganisms exceeded 10(5.5)/0.1 ml.

Original languageEnglish
JournalActa pathologica et microbiologica Scandinavica. Section B, Microbiology
Volume84B
Issue number5
Pages (from-to)259-64
Number of pages6
ISSN0105-0656
Publication statusPublished - 1976
Externally publishedYes

Keywords

  • Acetates
  • Aeromonas
  • Bacteria
  • Benzoates
  • Citrobacter
  • Dose-Response Relationship, Drug
  • Drug Resistance, Microbial
  • Enterobacteriaceae
  • Humans
  • Klebsiella pneumoniae
  • Pseudomonas
  • Renal Dialysis
  • Sulfonamides
  • Yeasts
  • Journal Article

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