The association between uric acid levels and different clinical manifestations of coronary artery disease

Trine R Larsen, Oke Gerke, Axel C P Diederichsen, Jess Lambrechtsen, Flemming H Steffensen, Niels P Sand, Lotte Saaby, Steen Antonsen, Hans Mickley

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Abstract

Aims Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). Patients and methods The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan. Hospitalized patients with suspected acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI concentrations (>0.03 μg/l) with subdivision according to the type of MI and other clinical conditions associated with myocardial injury, or (ii) nonelevated TnI concentrations (=0.03 μg/l). Results UA was not associated with the severity of CAC in asymptomatic individuals when adjusting for relevant risk factors. Patients with type 2 MI and patients with myocardial injury associated with conditions of myocardial ischemia showed significantly higher UA levels (0.390 mmol/l, P=0.002 and 0.400 mmol/l, P=0.001, respectively) than patients with type 1 MI (0.329 mmol/l), after adjusting for other risk factors. Conclusion UA was not correlated with the severity of CAC in asymptomatic middle-aged individuals, and patients with type 2 MI or ischemic myocardial injury were shown to have higher UA levels than type 1 MI patients. This observation is concordant with the hypothesis that UA might be involved in the pathophysiological mechanisms leading to an imbalance in the oxygen supply/demand ratio in type 2 MI and ischemic myocardial injury.

Original languageEnglish
JournalCoronary Artery Disease
Volume29
Issue number3
Pages (from-to)194-203
ISSN0954-6928
DOIs
Publication statusPublished - May 2018

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Uric Acid
Coronary Artery Disease
Troponin I
Wounds and Injuries
Oxygen

Keywords

  • Journal Article
  • Myocardial infarction
  • Atherosclerosis
  • Type 1 and type 2
  • Coronary artery calcification
  • Severity of Illness Index
  • Tomography, X-Ray Computed/methods
  • Correlation of Data
  • Humans
  • Middle Aged
  • Risk Factors
  • Uric Acid/blood
  • Male
  • Troponin I/blood
  • Vascular Calcification/diagnostic imaging
  • Myocardial Infarction/blood
  • Adult
  • Female
  • Aged
  • Coronary Vessels/diagnostic imaging
  • Coronary Artery Disease/blood

Cite this

@article{0188d64c2ed847ac96bac5a50cb8e565,
title = "The association between uric acid levels and different clinical manifestations of coronary artery disease",
abstract = "Aims Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). Patients and methods The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan. Hospitalized patients with suspected acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI concentrations (>0.03 μg/l) with subdivision according to the type of MI and other clinical conditions associated with myocardial injury, or (ii) nonelevated TnI concentrations (=0.03 μg/l). Results UA was not associated with the severity of CAC in asymptomatic individuals when adjusting for relevant risk factors. Patients with type 2 MI and patients with myocardial injury associated with conditions of myocardial ischemia showed significantly higher UA levels (0.390 mmol/l, P=0.002 and 0.400 mmol/l, P=0.001, respectively) than patients with type 1 MI (0.329 mmol/l), after adjusting for other risk factors. Conclusion UA was not correlated with the severity of CAC in asymptomatic middle-aged individuals, and patients with type 2 MI or ischemic myocardial injury were shown to have higher UA levels than type 1 MI patients. This observation is concordant with the hypothesis that UA might be involved in the pathophysiological mechanisms leading to an imbalance in the oxygen supply/demand ratio in type 2 MI and ischemic myocardial injury.",
keywords = "Journal Article, Myocardial infarction, Atherosclerosis, Type 1 and type 2, Coronary artery calcification, Severity of Illness Index, Tomography, X-Ray Computed/methods, Correlation of Data, Humans, Middle Aged, Risk Factors, Uric Acid/blood, Male, Troponin I/blood, Vascular Calcification/diagnostic imaging, Myocardial Infarction/blood, Adult, Female, Aged, Coronary Vessels/diagnostic imaging, Coronary Artery Disease/blood",
author = "Larsen, {Trine R} and Oke Gerke and Diederichsen, {Axel C P} and Jess Lambrechtsen and Steffensen, {Flemming H} and Sand, {Niels P} and Lotte Saaby and Steen Antonsen and Hans Mickley",
year = "2018",
month = "5",
doi = "10.1097/MCA.0000000000000593",
language = "English",
volume = "29",
pages = "194--203",
journal = "Coronary Artery Disease",
issn = "0954-6928",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

The association between uric acid levels and different clinical manifestations of coronary artery disease. / Larsen, Trine R; Gerke, Oke; Diederichsen, Axel C P; Lambrechtsen, Jess; Steffensen, Flemming H; Sand, Niels P; Saaby, Lotte; Antonsen, Steen; Mickley, Hans.

In: Coronary Artery Disease, Vol. 29, No. 3, 05.2018, p. 194-203.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The association between uric acid levels and different clinical manifestations of coronary artery disease

AU - Larsen, Trine R

AU - Gerke, Oke

AU - Diederichsen, Axel C P

AU - Lambrechtsen, Jess

AU - Steffensen, Flemming H

AU - Sand, Niels P

AU - Saaby, Lotte

AU - Antonsen, Steen

AU - Mickley, Hans

PY - 2018/5

Y1 - 2018/5

N2 - Aims Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). Patients and methods The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan. Hospitalized patients with suspected acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI concentrations (>0.03 μg/l) with subdivision according to the type of MI and other clinical conditions associated with myocardial injury, or (ii) nonelevated TnI concentrations (=0.03 μg/l). Results UA was not associated with the severity of CAC in asymptomatic individuals when adjusting for relevant risk factors. Patients with type 2 MI and patients with myocardial injury associated with conditions of myocardial ischemia showed significantly higher UA levels (0.390 mmol/l, P=0.002 and 0.400 mmol/l, P=0.001, respectively) than patients with type 1 MI (0.329 mmol/l), after adjusting for other risk factors. Conclusion UA was not correlated with the severity of CAC in asymptomatic middle-aged individuals, and patients with type 2 MI or ischemic myocardial injury were shown to have higher UA levels than type 1 MI patients. This observation is concordant with the hypothesis that UA might be involved in the pathophysiological mechanisms leading to an imbalance in the oxygen supply/demand ratio in type 2 MI and ischemic myocardial injury.

AB - Aims Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). Patients and methods The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan. Hospitalized patients with suspected acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI concentrations (>0.03 μg/l) with subdivision according to the type of MI and other clinical conditions associated with myocardial injury, or (ii) nonelevated TnI concentrations (=0.03 μg/l). Results UA was not associated with the severity of CAC in asymptomatic individuals when adjusting for relevant risk factors. Patients with type 2 MI and patients with myocardial injury associated with conditions of myocardial ischemia showed significantly higher UA levels (0.390 mmol/l, P=0.002 and 0.400 mmol/l, P=0.001, respectively) than patients with type 1 MI (0.329 mmol/l), after adjusting for other risk factors. Conclusion UA was not correlated with the severity of CAC in asymptomatic middle-aged individuals, and patients with type 2 MI or ischemic myocardial injury were shown to have higher UA levels than type 1 MI patients. This observation is concordant with the hypothesis that UA might be involved in the pathophysiological mechanisms leading to an imbalance in the oxygen supply/demand ratio in type 2 MI and ischemic myocardial injury.

KW - Journal Article

KW - Myocardial infarction

KW - Atherosclerosis

KW - Type 1 and type 2

KW - Coronary artery calcification

KW - Severity of Illness Index

KW - Tomography, X-Ray Computed/methods

KW - Correlation of Data

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Uric Acid/blood

KW - Male

KW - Troponin I/blood

KW - Vascular Calcification/diagnostic imaging

KW - Myocardial Infarction/blood

KW - Adult

KW - Female

KW - Aged

KW - Coronary Vessels/diagnostic imaging

KW - Coronary Artery Disease/blood

U2 - 10.1097/MCA.0000000000000593

DO - 10.1097/MCA.0000000000000593

M3 - Journal article

C2 - 29194090

VL - 29

SP - 194

EP - 203

JO - Coronary Artery Disease

JF - Coronary Artery Disease

SN - 0954-6928

IS - 3

ER -