The association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep - a cross-sectional study

Tatiana de Oliveira Sato, David M. Hallman, Jesper Kristiansen, Andreas Holtermann

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Abstract

BACKGROUND: The prevention and rehabilitation of multisite musculoskeletal pain would benefit from studies aiming to understand its underlying mechanism. Autonomic imbalance is a suggested mechanism for multisite pain, but hardly been studied during normal daily living. Therefore, the aim of the study is to investigate the association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep. METHODS: This study is based on data from the "Danish Physical activity cohort with objective measurements" among 568 blue-collar workers. Pain intensity scales were dichotomized according to the median of each scale, and the number of pain sites was calculated. No site was regarded as the pain-free, one site was considered as single-site musculoskeletal pain and pain in two or more sites was regarded as multisite musculoskeletal pain. Heart rate variability (HRV) was measured by an electrocardiogram system (ActiHeart) and physical activity using accelerometers (Actigraph). Crude and adjusted linear mixed models were applied to investigate the association between groups and cardiac autonomic regulation during work, leisure and sleep. RESULTS: There was no significant difference between groups and no significant interaction between groups and domains in the crude or adjusted models for any HRV index. Significant differences between domains were found in the crude and adjusted model for all indices, except SDNN; sleep time showed higher values than leisure and work time, except for LF and LF/HF, which were higher during work. CONCLUSION: This cross-sectional study showed that multisite musculoskeletal pain is not associated with imbalanced cardiac autonomic regulation during work, leisure and sleep time.

Original languageEnglish
Article number405
JournalBMC Musculoskeletal Disorders
Volume19
Issue number1
Number of pages10
ISSN1471-2474
DOIs
Publication statusPublished - 20. Nov 2018

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Leisure Activities
Cross-Sectional Studies
Linear Models
Electrocardiography

Keywords

  • Autonomic nervous system
  • Chronic pain
  • Heart rate variability
  • Physical activity
  • Leisure Activities
  • Heart Rate/physiology
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Exercise/physiology
  • Male
  • Pain Measurement/methods
  • Sleep/physiology
  • Musculoskeletal Pain/diagnosis
  • Adult
  • Female
  • Work/physiology
  • Cohort Studies

Cite this

de Oliveira Sato, Tatiana ; Hallman, David M. ; Kristiansen, Jesper ; Holtermann, Andreas. / The association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep - a cross-sectional study. In: BMC Musculoskeletal Disorders. 2018 ; Vol. 19, No. 1.
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The association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep - a cross-sectional study. / de Oliveira Sato, Tatiana; Hallman, David M.; Kristiansen, Jesper; Holtermann, Andreas.

In: BMC Musculoskeletal Disorders, Vol. 19, No. 1, 405, 20.11.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - The association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep - a cross-sectional study

AU - de Oliveira Sato, Tatiana

AU - Hallman, David M.

AU - Kristiansen, Jesper

AU - Holtermann, Andreas

PY - 2018/11/20

Y1 - 2018/11/20

N2 - BACKGROUND: The prevention and rehabilitation of multisite musculoskeletal pain would benefit from studies aiming to understand its underlying mechanism. Autonomic imbalance is a suggested mechanism for multisite pain, but hardly been studied during normal daily living. Therefore, the aim of the study is to investigate the association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep. METHODS: This study is based on data from the "Danish Physical activity cohort with objective measurements" among 568 blue-collar workers. Pain intensity scales were dichotomized according to the median of each scale, and the number of pain sites was calculated. No site was regarded as the pain-free, one site was considered as single-site musculoskeletal pain and pain in two or more sites was regarded as multisite musculoskeletal pain. Heart rate variability (HRV) was measured by an electrocardiogram system (ActiHeart) and physical activity using accelerometers (Actigraph). Crude and adjusted linear mixed models were applied to investigate the association between groups and cardiac autonomic regulation during work, leisure and sleep. RESULTS: There was no significant difference between groups and no significant interaction between groups and domains in the crude or adjusted models for any HRV index. Significant differences between domains were found in the crude and adjusted model for all indices, except SDNN; sleep time showed higher values than leisure and work time, except for LF and LF/HF, which were higher during work. CONCLUSION: This cross-sectional study showed that multisite musculoskeletal pain is not associated with imbalanced cardiac autonomic regulation during work, leisure and sleep time.

AB - BACKGROUND: The prevention and rehabilitation of multisite musculoskeletal pain would benefit from studies aiming to understand its underlying mechanism. Autonomic imbalance is a suggested mechanism for multisite pain, but hardly been studied during normal daily living. Therefore, the aim of the study is to investigate the association between multisite musculoskeletal pain and cardiac autonomic modulation during work, leisure and sleep. METHODS: This study is based on data from the "Danish Physical activity cohort with objective measurements" among 568 blue-collar workers. Pain intensity scales were dichotomized according to the median of each scale, and the number of pain sites was calculated. No site was regarded as the pain-free, one site was considered as single-site musculoskeletal pain and pain in two or more sites was regarded as multisite musculoskeletal pain. Heart rate variability (HRV) was measured by an electrocardiogram system (ActiHeart) and physical activity using accelerometers (Actigraph). Crude and adjusted linear mixed models were applied to investigate the association between groups and cardiac autonomic regulation during work, leisure and sleep. RESULTS: There was no significant difference between groups and no significant interaction between groups and domains in the crude or adjusted models for any HRV index. Significant differences between domains were found in the crude and adjusted model for all indices, except SDNN; sleep time showed higher values than leisure and work time, except for LF and LF/HF, which were higher during work. CONCLUSION: This cross-sectional study showed that multisite musculoskeletal pain is not associated with imbalanced cardiac autonomic regulation during work, leisure and sleep time.

KW - Autonomic nervous system

KW - Chronic pain

KW - Heart rate variability

KW - Physical activity

KW - Leisure Activities

KW - Heart Rate/physiology

KW - Cross-Sectional Studies

KW - Humans

KW - Middle Aged

KW - Exercise/physiology

KW - Male

KW - Pain Measurement/methods

KW - Sleep/physiology

KW - Musculoskeletal Pain/diagnosis

KW - Adult

KW - Female

KW - Work/physiology

KW - Cohort Studies

U2 - 10.1186/s12891-018-2312-3

DO - 10.1186/s12891-018-2312-3

M3 - Journal article

C2 - 30458750

AN - SCOPUS:85056803538

VL - 19

JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

SN - 1471-2474

IS - 1

M1 - 405

ER -