Temperament, character and serotonin activity in the human brain

a positron emission tomography study based on a general population cohort

L Tuominen, J Salo, J Hirvonen, Kjell Någren, P Laine, T Melartin, E Isometsä, J Viikari, C R Cloninger, O Raitakari, J Hietala, L Keltikangas-Järvinen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension 'harm avoidance' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an 'oversampling' study design. Method Subjects consistently in either upper or lower quartiles for the HA trait were selected from a population-based cohort in Finland (n = 2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high- and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BPND) in high- and low-HA groups estimated with PET and [11C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([11C]MADAM). In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions.
Original languageEnglish
JournalPsychological Medicine
Volume43
Issue number4
Pages (from-to)881-94
ISSN0033-2917
DOIs
Publication statusPublished - 2013

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Human Activities
Population
Equipment and Supplies
Serotonin Plasma Membrane Transport Proteins
Finland
Outcome Assessment (Health Care)
N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine

Cite this

Tuominen, L ; Salo, J ; Hirvonen, J ; Någren, Kjell ; Laine, P ; Melartin, T ; Isometsä, E ; Viikari, J ; Cloninger, C R ; Raitakari, O ; Hietala, J ; Keltikangas-Järvinen, L. / Temperament, character and serotonin activity in the human brain : a positron emission tomography study based on a general population cohort. In: Psychological Medicine. 2013 ; Vol. 43, No. 4. pp. 881-94.
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title = "Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort",
abstract = "The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension 'harm avoidance' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an 'oversampling' study design. Method Subjects consistently in either upper or lower quartiles for the HA trait were selected from a population-based cohort in Finland (n = 2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high- and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BPND) in high- and low-HA groups estimated with PET and [11C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([11C]MADAM). In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions.",
author = "L Tuominen and J Salo and J Hirvonen and Kjell N{\aa}gren and P Laine and T Melartin and E Isomets{\"a} and J Viikari and Cloninger, {C R} and O Raitakari and J Hietala and L Keltikangas-J{\"a}rvinen",
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language = "English",
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Tuominen, L, Salo, J, Hirvonen, J, Någren, K, Laine, P, Melartin, T, Isometsä, E, Viikari, J, Cloninger, CR, Raitakari, O, Hietala, J & Keltikangas-Järvinen, L 2013, 'Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort', Psychological Medicine, vol. 43, no. 4, pp. 881-94. https://doi.org/10.1017/S003329171200164X

Temperament, character and serotonin activity in the human brain : a positron emission tomography study based on a general population cohort. / Tuominen, L; Salo, J; Hirvonen, J; Någren, Kjell; Laine, P; Melartin, T; Isometsä, E; Viikari, J; Cloninger, C R; Raitakari, O; Hietala, J; Keltikangas-Järvinen, L.

In: Psychological Medicine, Vol. 43, No. 4, 2013, p. 881-94.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Temperament, character and serotonin activity in the human brain

T2 - a positron emission tomography study based on a general population cohort

AU - Tuominen, L

AU - Salo, J

AU - Hirvonen, J

AU - Någren, Kjell

AU - Laine, P

AU - Melartin, T

AU - Isometsä, E

AU - Viikari, J

AU - Cloninger, C R

AU - Raitakari, O

AU - Hietala, J

AU - Keltikangas-Järvinen, L

PY - 2013

Y1 - 2013

N2 - The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension 'harm avoidance' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an 'oversampling' study design. Method Subjects consistently in either upper or lower quartiles for the HA trait were selected from a population-based cohort in Finland (n = 2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high- and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BPND) in high- and low-HA groups estimated with PET and [11C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([11C]MADAM). In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions.

AB - The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension 'harm avoidance' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an 'oversampling' study design. Method Subjects consistently in either upper or lower quartiles for the HA trait were selected from a population-based cohort in Finland (n = 2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high- and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BPND) in high- and low-HA groups estimated with PET and [11C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([11C]MADAM). In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions.

U2 - 10.1017/S003329171200164X

DO - 10.1017/S003329171200164X

M3 - Journal article

VL - 43

SP - 881

EP - 894

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 4

ER -