@article{15d33c7efdf348f9b220b36fbcc6bc7d,
title = "Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides",
abstract = "SARS-CoV-2 Spike protein RBD interacts with the hACE2 receptor toinitiate cell entry and infection. We set out to develop lactam-based i,i + 4 stapled hACE2 peptides targeting SARS-CoV-2. In vitro screeningdemonstrates the inhibition of the Spike protein RBD-hACE2 complexformation by the hACE221-55A36K-F40E stapled peptide (IC50: 3.6 lM,Kd: 2.1 lM), suggesting that hACE2 peptidomimetics could form thebasis for the development of anti-COVID-19 therapeutics.",
author = "Maas, {Marijn N.} and Hintzen, {Jordi C. J.} and L{\"o}ffler, {Philipp M. G.} and Jasmin Mecinovi{\'c}",
year = "2021",
doi = "10.1039/D0CC08387A",
language = "English",
volume = "57",
pages = "3283--3286",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "26",
}