TY - JOUR
T1 - Target isoforms are an overlooked challenge and opportunity in chimeric antigen receptor cell therapy
AU - Barnkob, Mike Bogetofte
AU - Vitting-Seerup, Kristoffer
AU - Olsen, Lars Rønn
PY - 2022/4/20
Y1 - 2022/4/20
N2 - The development of novel chimeric antigen receptor (CAR) cell therapies is rapidly growing, with 299 new agents being reported and 109 new clinical trials initiated so far this year. One critical lesson from approved CD19-specific CAR therapies is that target isoform switching has been shown to cause tumour relapse, but little is known about the isoforms of CAR targets in solid cancers. Here we assess the protein isoform landscape and identify both the challenges and opportunities protein isoform switching present as CAR therapy is applied to solid cancers.
AB - The development of novel chimeric antigen receptor (CAR) cell therapies is rapidly growing, with 299 new agents being reported and 109 new clinical trials initiated so far this year. One critical lesson from approved CD19-specific CAR therapies is that target isoform switching has been shown to cause tumour relapse, but little is known about the isoforms of CAR targets in solid cancers. Here we assess the protein isoform landscape and identify both the challenges and opportunities protein isoform switching present as CAR therapy is applied to solid cancers.
U2 - 10.1093/immadv/ltac009
DO - 10.1093/immadv/ltac009
M3 - Comment/debate
C2 - 35919495
VL - 2
JO - Immunotherapy Advances
JF - Immunotherapy Advances
IS - 1
M1 - ltac009
ER -