Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.

Oscar Norbeck, Adiba Isa, Christoph Pöhlmann, Kristina Broliden, Victoria Kasprowicz, Paul Bowness, Paul Klenerman, Thomas Tolfvenstam

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.
Original languageEnglish
JournalJournal of Virology
Volume79
Issue number18
Pages (from-to)12117-21
Number of pages4
ISSN0022-538X
DOIs
Publication statusPublished - 1. Sep 2005

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Parvoviridae Infections
Protoparvovirus
T-lymphocytes
Virus Diseases
infection
B19 virus
viral diseases of animals and humans
Human Parvovirus B19
acute course
Parvovirus
live vaccines
Acute Disease
animal models

Keywords

  • Acute Disease
  • Adult
  • Amino Acid Sequence
  • Animals
  • Antigens, Viral
  • CD8-Positive T-Lymphocytes
  • Capsid Proteins
  • Epitopes
  • Female
  • Humans
  • Mice
  • Middle Aged
  • Molecular Sequence Data
  • Parvoviridae Infections
  • Parvovirus B19, Human
  • Prospective Studies
  • Time Factors
  • Viral Nonstructural Proteins

Cite this

Norbeck, O., Isa, A., Pöhlmann, C., Broliden, K., Kasprowicz, V., Bowness, P., ... Tolfvenstam, T. (2005). Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. Journal of Virology, 79(18), 12117-21. https://doi.org/10.1128/JVI.79.18.12117-12121.2005
Norbeck, Oscar ; Isa, Adiba ; Pöhlmann, Christoph ; Broliden, Kristina ; Kasprowicz, Victoria ; Bowness, Paul ; Klenerman, Paul ; Tolfvenstam, Thomas. / Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. In: Journal of Virology. 2005 ; Vol. 79, No. 18. pp. 12117-21.
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abstract = "Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.",
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Norbeck, O, Isa, A, Pöhlmann, C, Broliden, K, Kasprowicz, V, Bowness, P, Klenerman, P & Tolfvenstam, T 2005, 'Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.', Journal of Virology, vol. 79, no. 18, pp. 12117-21. https://doi.org/10.1128/JVI.79.18.12117-12121.2005

Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. / Norbeck, Oscar; Isa, Adiba; Pöhlmann, Christoph; Broliden, Kristina; Kasprowicz, Victoria; Bowness, Paul; Klenerman, Paul; Tolfvenstam, Thomas.

In: Journal of Virology, Vol. 79, No. 18, 01.09.2005, p. 12117-21.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.

AU - Norbeck, Oscar

AU - Isa, Adiba

AU - Pöhlmann, Christoph

AU - Broliden, Kristina

AU - Kasprowicz, Victoria

AU - Bowness, Paul

AU - Klenerman, Paul

AU - Tolfvenstam, Thomas

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

AB - Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

KW - Acute Disease

KW - Adult

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, Viral

KW - CD8-Positive T-Lymphocytes

KW - Capsid Proteins

KW - Epitopes

KW - Female

KW - Humans

KW - Mice

KW - Middle Aged

KW - Molecular Sequence Data

KW - Parvoviridae Infections

KW - Parvovirus B19, Human

KW - Prospective Studies

KW - Time Factors

KW - Viral Nonstructural Proteins

U2 - 10.1128/JVI.79.18.12117-12121.2005

DO - 10.1128/JVI.79.18.12117-12121.2005

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Norbeck O, Isa A, Pöhlmann C, Broliden K, Kasprowicz V, Bowness P et al. Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans. Journal of Virology. 2005 Sep 1;79(18):12117-21. https://doi.org/10.1128/JVI.79.18.12117-12121.2005