Surface Modification Enabling Reproducible Cantilever Functionalization for Industrial Gas Sensors

Daniel Mamou, Lawrence Nsubuga, Tatiana Lisboa Marcondes, Simon Overgaard Høegh, Jeanette Hvam, Florian Niekiel, Fabian Lofink, Horst-Günter Rubahn, Roana de Oliveira Hansen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Micro-cantilever sensors are a known reliable tool for gas sensing in industrial applications. We have demonstrated the application of cantilever sensors on the detection of a meat freshness volatile biomarker (cadaverine), for determination of meat and fish precise expiration dates. For achieving correct target selectivity, the cantilevers need to be functionalized with a cadaverineselective
binder, based on a cyclam-derivative. Cantilever surface properties such as surface energy strongly influence the binder morphology and material clustering and, therefore, target binding. In this paper, we explore how chemical and physical surface treatments influence cantilever surface, binder morphology/clustering and binding capabilities. Sensor measurements with non-controlled surface properties are presented, followed by investigations on the binder morphology versus surface energy and cadaverine capture. We demonstrated a method for hindering binder crystallization on functionalized surfaces, leading to reproducible target capture. The results show that cantilever surface treatment is a promising method for achieving a high degree of functionalization reproducibility for industrial cantilever sensors, by controlling binder morphology and uniformity.
Original languageEnglish
Article number6041
Issue number18
Number of pages8
Publication statusPublished - 9. Sept 2021


  • Cadaverine sensing
  • Cantilever gas sensing
  • Surface energy
  • Surface modification
  • Reproducibility of Results
  • Animals
  • Surface Properties
  • Biosensing Techniques


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