Supercooled smectic nanoparticles: a potential novel carrier system for poorly water soluble drugs

Judith Kuntsche; K Westesen; M Drechsler; Michel Koch; H Bunjes

Supercooled smectic nanoparticles: a potential novel carrier system for poorly water soluble drugs

Judith Kuntsche, K Westesen, M Drechsler, Michel Koch, H Bunjes

Department of Physics, Chemistry and Pharmacy

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The possibility of preparing nanoparticles in the supercooled thermotropic liquid crystalline state from cholesterol esters with saturated acyl chains as well as the incorporation of model drugs into the dispersions was investigated using cholesteryl myristate (CM) as a model cholesterol ester.

Original language	English
Journal	Pharmaceutical Research
Volume	21
Issue number	10
Pages (from-to)	1834-43
Number of pages	10
ISSN	0724-8741
Publication status	Published - 2004

Keywords

Calorimetry, Differential Scanning
Cholesterol Esters
Cold Temperature
Drug Carriers
Excipients
Freeze Fracturing
Lasers
Microscopy, Polarization
Microspheres
Particle Size
Pharmaceutical Preparations
Rheology
Solubility
Solvents
Viscosity
X-Ray Diffraction

SDU Link

Check access to the material in SDU Library's search engine

Cite this

@article{1a442c20031c4d87a99ccfb6c95e4105,

title = "Supercooled smectic nanoparticles: a potential novel carrier system for poorly water soluble drugs",

abstract = "The possibility of preparing nanoparticles in the supercooled thermotropic liquid crystalline state from cholesterol esters with saturated acyl chains as well as the incorporation of model drugs into the dispersions was investigated using cholesteryl myristate (CM) as a model cholesterol ester.",

keywords = "Calorimetry, Differential Scanning, Cholesterol Esters, Cold Temperature, Drug Carriers, Excipients, Freeze Fracturing, Lasers, Microscopy, Polarization, Microspheres, Particle Size, Pharmaceutical Preparations, Rheology, Solubility, Solvents, Viscosity, X-Ray Diffraction",

author = "Judith Kuntsche and K Westesen and M Drechsler and Michel Koch and H Bunjes",

year = "2004",

language = "English",

volume = "21",

pages = "1834--43",

journal = "Pharmaceutical Research",

issn = "0724-8741",

publisher = "Springer",

number = "10",

}

TY - JOUR

T1 - Supercooled smectic nanoparticles

T2 - a potential novel carrier system for poorly water soluble drugs

AU - Kuntsche, Judith

AU - Westesen, K

AU - Drechsler, M

AU - Koch, Michel

AU - Bunjes, H

PY - 2004

Y1 - 2004

N2 - The possibility of preparing nanoparticles in the supercooled thermotropic liquid crystalline state from cholesterol esters with saturated acyl chains as well as the incorporation of model drugs into the dispersions was investigated using cholesteryl myristate (CM) as a model cholesterol ester.

AB - The possibility of preparing nanoparticles in the supercooled thermotropic liquid crystalline state from cholesterol esters with saturated acyl chains as well as the incorporation of model drugs into the dispersions was investigated using cholesteryl myristate (CM) as a model cholesterol ester.

KW - Calorimetry, Differential Scanning

KW - Cholesterol Esters

KW - Cold Temperature

KW - Drug Carriers

KW - Excipients

KW - Freeze Fracturing

KW - Lasers

KW - Microscopy, Polarization

KW - Microspheres

KW - Particle Size

KW - Pharmaceutical Preparations

KW - Rheology

KW - Solubility

KW - Solvents

KW - Viscosity

KW - X-Ray Diffraction

M3 - Journal article

C2 - 15553230

SN - 0724-8741

VL - 21

SP - 1834

EP - 1843

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 10

ER -

Supercooled smectic nanoparticles: a potential novel carrier system for poorly water soluble drugs

Abstract

Keywords

SDU Link

Fingerprint

Cite this