Stroke research in GenomEUtwin

D. Gaist, N.L. Pedersen, M. Koskenvuo, S. Bak, S. Giampaoli, K. Christensen, J. Kaprio

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Stroke is one of the leading causes of severe disability and death in the world. In the present article we outline possibilities and limitations for future stroke research within the GenomEUtwin. The combined sample of twins born before 1958 from Denmark, Finland, and Sweden, and available for follow-up into the second millennium for non-fatal and fatal stroke events through national inpatient and death registers exceeds 70,000 twin pairs. This sample size will enable the study of genetic influences on stroke and major stroke subtypes. Large samples of twins in GenomEUtwin have been followed up repeatedly through interviews and questionnaires concerning a variety of exposures and potential risk factors for stroke. We briefly outline how this information can be combined with the health register information for epidemiologic and genetic epidemiologic studies of stroke. We also present the number of twin pairs concordant and discordant for stroke in Denmark, Finland and Sweden, and time lags between events for twins concordant for stroke. This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies.
Original languageEnglish
JournalTwin research
Volume6
Issue number5
Pages (from-to)442-447
ISSN1369-0523
DOIs
Publication statusPublished - 2003

Fingerprint

Research
Denmark
Finland
Sample Size
Inpatients
Epidemiologic Studies
Interviews
Health

Cite this

Gaist, D., Pedersen, N. L., Koskenvuo, M., Bak, S., Giampaoli, S., Christensen, K., & Kaprio, J. (2003). Stroke research in GenomEUtwin. Twin research, 6(5), 442-447. https://doi.org/10.1375/136905203770326448
Gaist, D. ; Pedersen, N.L. ; Koskenvuo, M. ; Bak, S. ; Giampaoli, S. ; Christensen, K. ; Kaprio, J. / Stroke research in GenomEUtwin. In: Twin research. 2003 ; Vol. 6, No. 5. pp. 442-447.
@article{86acbe30ba9a11dc9626000ea68e967b,
title = "Stroke research in GenomEUtwin",
abstract = "Stroke is one of the leading causes of severe disability and death in the world. In the present article we outline possibilities and limitations for future stroke research within the GenomEUtwin. The combined sample of twins born before 1958 from Denmark, Finland, and Sweden, and available for follow-up into the second millennium for non-fatal and fatal stroke events through national inpatient and death registers exceeds 70,000 twin pairs. This sample size will enable the study of genetic influences on stroke and major stroke subtypes. Large samples of twins in GenomEUtwin have been followed up repeatedly through interviews and questionnaires concerning a variety of exposures and potential risk factors for stroke. We briefly outline how this information can be combined with the health register information for epidemiologic and genetic epidemiologic studies of stroke. We also present the number of twin pairs concordant and discordant for stroke in Denmark, Finland and Sweden, and time lags between events for twins concordant for stroke. This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies.",
author = "D. Gaist and N.L. Pedersen and M. Koskenvuo and S. Bak and S. Giampaoli and K. Christensen and J. Kaprio",
year = "2003",
doi = "10.1375/136905203770326448",
language = "English",
volume = "6",
pages = "442--447",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Heinemann",
number = "5",

}

Gaist, D, Pedersen, NL, Koskenvuo, M, Bak, S, Giampaoli, S, Christensen, K & Kaprio, J 2003, 'Stroke research in GenomEUtwin', Twin research, vol. 6, no. 5, pp. 442-447. https://doi.org/10.1375/136905203770326448

Stroke research in GenomEUtwin. / Gaist, D.; Pedersen, N.L.; Koskenvuo, M.; Bak, S.; Giampaoli, S.; Christensen, K.; Kaprio, J.

In: Twin research, Vol. 6, No. 5, 2003, p. 442-447.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Stroke research in GenomEUtwin

AU - Gaist, D.

AU - Pedersen, N.L.

AU - Koskenvuo, M.

AU - Bak, S.

AU - Giampaoli, S.

AU - Christensen, K.

AU - Kaprio, J.

PY - 2003

Y1 - 2003

N2 - Stroke is one of the leading causes of severe disability and death in the world. In the present article we outline possibilities and limitations for future stroke research within the GenomEUtwin. The combined sample of twins born before 1958 from Denmark, Finland, and Sweden, and available for follow-up into the second millennium for non-fatal and fatal stroke events through national inpatient and death registers exceeds 70,000 twin pairs. This sample size will enable the study of genetic influences on stroke and major stroke subtypes. Large samples of twins in GenomEUtwin have been followed up repeatedly through interviews and questionnaires concerning a variety of exposures and potential risk factors for stroke. We briefly outline how this information can be combined with the health register information for epidemiologic and genetic epidemiologic studies of stroke. We also present the number of twin pairs concordant and discordant for stroke in Denmark, Finland and Sweden, and time lags between events for twins concordant for stroke. This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies.

AB - Stroke is one of the leading causes of severe disability and death in the world. In the present article we outline possibilities and limitations for future stroke research within the GenomEUtwin. The combined sample of twins born before 1958 from Denmark, Finland, and Sweden, and available for follow-up into the second millennium for non-fatal and fatal stroke events through national inpatient and death registers exceeds 70,000 twin pairs. This sample size will enable the study of genetic influences on stroke and major stroke subtypes. Large samples of twins in GenomEUtwin have been followed up repeatedly through interviews and questionnaires concerning a variety of exposures and potential risk factors for stroke. We briefly outline how this information can be combined with the health register information for epidemiologic and genetic epidemiologic studies of stroke. We also present the number of twin pairs concordant and discordant for stroke in Denmark, Finland and Sweden, and time lags between events for twins concordant for stroke. This information illustrates that the number of affected sib pairs for linkage studies is relatively limited, but the sample sizes are promising for association studies.

U2 - 10.1375/136905203770326448

DO - 10.1375/136905203770326448

M3 - Journal article

VL - 6

SP - 442

EP - 447

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 5

ER -

Gaist D, Pedersen NL, Koskenvuo M, Bak S, Giampaoli S, Christensen K et al. Stroke research in GenomEUtwin. Twin research. 2003;6(5):442-447. https://doi.org/10.1375/136905203770326448