Straight versus tortuous retinal arteries in relation to blood pressure and genetics

N C B B Taarnhøj, I C Munch, B Sander, L Kessel, J L Hougaard, K Kyvik, T I A Sørensen, M Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND/AIMS: To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity and the association between tortuosity and various health indices in healthy young to middle-aged persons. METHODS: This cross-sectional study included 57 monozygotic and 52 dizygotic same-sex healthy twin pairs, aged 20 to 46 years, who were characterised by determination of retinal vessel diameters, arterial blood pressure, blood glucose, body mass index, smoking habits and retinal arterial tortuosity, using a three-level grading scale (straight, wavy, tortuous). Heritability of retinal arterial tortuosity was estimated using structural equation modelling. RESULTS: Of 218 subjects, 79 (36.2%) had straight retinal arteries, 110 (50.5%) had wavy arteries, and 29 (13.3%) had tortuous arteries. Heritability of tortuosity was 82% (CI(95 )64, 92%), with unshared environmental factors accounting for the remaining 18% (CI(95 )8, 36%). Increasing values of mean arterial blood pressure and body mass index were both associated with decreasing levels of retinal arterial tortuosity. CONCLUSION: There was a large variation in tortuosity of retinal arteries in these healthy subjects and the predominant determinant was genetic influence, accounting for 82% of the observed variation in tortuosity.
Original languageEnglish
JournalBritish Journal of Ophthalmology
Volume92
Issue number8
Pages (from-to)1055-1060
Number of pages5
ISSN0007-1161
DOIs
Publication statusPublished - 1. Aug 2008

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Retinal Artery
Arterial Pressure
Body Mass Index
Habits
Cross-Sectional Studies
Smoking
Arterial Tortuosity Syndrome
Health

Cite this

Taarnhøj, N. C. B. B., Munch, I. C., Sander, B., Kessel, L., Hougaard, J. L., Kyvik, K., ... Larsen, M. (2008). Straight versus tortuous retinal arteries in relation to blood pressure and genetics. British Journal of Ophthalmology, 92(8), 1055-1060. https://doi.org/10.1136/bjo.2007.134593
Taarnhøj, N C B B ; Munch, I C ; Sander, B ; Kessel, L ; Hougaard, J L ; Kyvik, K ; Sørensen, T I A ; Larsen, M. / Straight versus tortuous retinal arteries in relation to blood pressure and genetics. In: British Journal of Ophthalmology. 2008 ; Vol. 92, No. 8. pp. 1055-1060.
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abstract = "BACKGROUND/AIMS: To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity and the association between tortuosity and various health indices in healthy young to middle-aged persons. METHODS: This cross-sectional study included 57 monozygotic and 52 dizygotic same-sex healthy twin pairs, aged 20 to 46 years, who were characterised by determination of retinal vessel diameters, arterial blood pressure, blood glucose, body mass index, smoking habits and retinal arterial tortuosity, using a three-level grading scale (straight, wavy, tortuous). Heritability of retinal arterial tortuosity was estimated using structural equation modelling. RESULTS: Of 218 subjects, 79 (36.2{\%}) had straight retinal arteries, 110 (50.5{\%}) had wavy arteries, and 29 (13.3{\%}) had tortuous arteries. Heritability of tortuosity was 82{\%} (CI(95 )64, 92{\%}), with unshared environmental factors accounting for the remaining 18{\%} (CI(95 )8, 36{\%}). Increasing values of mean arterial blood pressure and body mass index were both associated with decreasing levels of retinal arterial tortuosity. CONCLUSION: There was a large variation in tortuosity of retinal arteries in these healthy subjects and the predominant determinant was genetic influence, accounting for 82{\%} of the observed variation in tortuosity.",
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Taarnhøj, NCBB, Munch, IC, Sander, B, Kessel, L, Hougaard, JL, Kyvik, K, Sørensen, TIA & Larsen, M 2008, 'Straight versus tortuous retinal arteries in relation to blood pressure and genetics', British Journal of Ophthalmology, vol. 92, no. 8, pp. 1055-1060. https://doi.org/10.1136/bjo.2007.134593

Straight versus tortuous retinal arteries in relation to blood pressure and genetics. / Taarnhøj, N C B B; Munch, I C; Sander, B; Kessel, L; Hougaard, J L; Kyvik, K; Sørensen, T I A; Larsen, M.

In: British Journal of Ophthalmology, Vol. 92, No. 8, 01.08.2008, p. 1055-1060.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Straight versus tortuous retinal arteries in relation to blood pressure and genetics

AU - Taarnhøj, N C B B

AU - Munch, I C

AU - Sander, B

AU - Kessel, L

AU - Hougaard, J L

AU - Kyvik, K

AU - Sørensen, T I A

AU - Larsen, M

PY - 2008/8/1

Y1 - 2008/8/1

N2 - BACKGROUND/AIMS: To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity and the association between tortuosity and various health indices in healthy young to middle-aged persons. METHODS: This cross-sectional study included 57 monozygotic and 52 dizygotic same-sex healthy twin pairs, aged 20 to 46 years, who were characterised by determination of retinal vessel diameters, arterial blood pressure, blood glucose, body mass index, smoking habits and retinal arterial tortuosity, using a three-level grading scale (straight, wavy, tortuous). Heritability of retinal arterial tortuosity was estimated using structural equation modelling. RESULTS: Of 218 subjects, 79 (36.2%) had straight retinal arteries, 110 (50.5%) had wavy arteries, and 29 (13.3%) had tortuous arteries. Heritability of tortuosity was 82% (CI(95 )64, 92%), with unshared environmental factors accounting for the remaining 18% (CI(95 )8, 36%). Increasing values of mean arterial blood pressure and body mass index were both associated with decreasing levels of retinal arterial tortuosity. CONCLUSION: There was a large variation in tortuosity of retinal arteries in these healthy subjects and the predominant determinant was genetic influence, accounting for 82% of the observed variation in tortuosity.

AB - BACKGROUND/AIMS: To assess the relative influence of genetic and environmental factors on retinal arterial tortuosity and the association between tortuosity and various health indices in healthy young to middle-aged persons. METHODS: This cross-sectional study included 57 monozygotic and 52 dizygotic same-sex healthy twin pairs, aged 20 to 46 years, who were characterised by determination of retinal vessel diameters, arterial blood pressure, blood glucose, body mass index, smoking habits and retinal arterial tortuosity, using a three-level grading scale (straight, wavy, tortuous). Heritability of retinal arterial tortuosity was estimated using structural equation modelling. RESULTS: Of 218 subjects, 79 (36.2%) had straight retinal arteries, 110 (50.5%) had wavy arteries, and 29 (13.3%) had tortuous arteries. Heritability of tortuosity was 82% (CI(95 )64, 92%), with unshared environmental factors accounting for the remaining 18% (CI(95 )8, 36%). Increasing values of mean arterial blood pressure and body mass index were both associated with decreasing levels of retinal arterial tortuosity. CONCLUSION: There was a large variation in tortuosity of retinal arteries in these healthy subjects and the predominant determinant was genetic influence, accounting for 82% of the observed variation in tortuosity.

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DO - 10.1136/bjo.2007.134593

M3 - Journal article

VL - 92

SP - 1055

EP - 1060

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 8

ER -