Stoppage in Autism Spectrum Disorders

Therese K Grønborg, Stefan N Hansen, Svend V Nielsen, Axel Skytthe, Erik T Parner

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume45
Issue number11
Pages (from-to)3509-19
ISSN0162-3257
DOIs
Publication statusPublished - Nov 2015

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Siblings
Autism Spectrum Disorder

Keywords

  • Autism spectrum disorder
  • Sibling recurrence risk
  • Stoppage

Cite this

Grønborg, T. K., Hansen, S. N., Nielsen, S. V., Skytthe, A., & Parner, E. T. (2015). Stoppage in Autism Spectrum Disorders. Journal of Autism and Developmental Disorders, 45(11), 3509-19. https://doi.org/10.1007/s10803-015-2497-3
Grønborg, Therese K ; Hansen, Stefan N ; Nielsen, Svend V ; Skytthe, Axel ; Parner, Erik T. / Stoppage in Autism Spectrum Disorders. In: Journal of Autism and Developmental Disorders. 2015 ; Vol. 45, No. 11. pp. 3509-19.
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Grønborg, TK, Hansen, SN, Nielsen, SV, Skytthe, A & Parner, ET 2015, 'Stoppage in Autism Spectrum Disorders', Journal of Autism and Developmental Disorders, vol. 45, no. 11, pp. 3509-19. https://doi.org/10.1007/s10803-015-2497-3

Stoppage in Autism Spectrum Disorders. / Grønborg, Therese K; Hansen, Stefan N; Nielsen, Svend V; Skytthe, Axel; Parner, Erik T.

In: Journal of Autism and Developmental Disorders, Vol. 45, No. 11, 11.2015, p. 3509-19.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Stoppage in Autism Spectrum Disorders

AU - Grønborg, Therese K

AU - Hansen, Stefan N

AU - Nielsen, Svend V

AU - Skytthe, Axel

AU - Parner, Erik T

PY - 2015/11

Y1 - 2015/11

N2 - Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders.

AB - Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders.

KW - Autism spectrum disorder

KW - Sibling recurrence risk

KW - Stoppage

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JO - Journal of Autism and Developmental Disorders

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