Stimulation of adult oligodendrogenesis by myelin-specific T cells

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In multiple sclerosis (MS), myelin-specific T cells are normally associated with destruction of myelin and axonal damage. However, in acute MS plaque, remyelination occurs concurrent with T-cell infiltration, which raises the question of whether T cells might stimulate myelin repair. We investigated the effect of myelin-specific T cells on oligodendrocyte formation at sites of axonal damage in the mouse hippocampal dentate gyrus. Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25% increase in the numbers of oligodendrocytes. In contrast, T cells specific for ovalbumin did not stimulate the formation of new oligodendrocytes. In addition, infiltration of myelin-specific T cells enhanced the sprouting response of calretinergic associational/commissural fibers within the dentate gyrus. These results have implications for the perception of MS pathogenesis because they show that infiltrating myelin-specific T cells can stimulate oligodendrogenesis in the adult central nervous system.
Original languageEnglish
JournalAmerican Journal of Pathology
Volume179
Issue number4
Pages (from-to)2028-41
Number of pages14
ISSN0002-9440
DOIs
Publication statusPublished - 2011

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Myelin Sheath
Oligodendroglia
Myelin Proteolipid Protein
Chondroitin Sulfates
Ovalbumin
Central Nervous System

Keywords

  • Aging
  • Animals
  • Axons
  • Calcium-Binding Protein, Vitamin D-Dependent
  • Cell Count
  • Cell Movement
  • Cell Proliferation
  • Cytokines
  • Dentate Gyrus
  • Female
  • Mice
  • Myelin Proteolipid Protein
  • Myelin Sheath
  • Nerve Degeneration
  • Neurogenesis
  • Neurons, Afferent
  • Oligodendroglia
  • Organ Specificity
  • Perforant Pathway
  • RNA, Messenger
  • T-Lymphocytes

Cite this

@article{73592db9c30b48ccbecde4b475f22da9,
title = "Stimulation of adult oligodendrogenesis by myelin-specific T cells",
abstract = "In multiple sclerosis (MS), myelin-specific T cells are normally associated with destruction of myelin and axonal damage. However, in acute MS plaque, remyelination occurs concurrent with T-cell infiltration, which raises the question of whether T cells might stimulate myelin repair. We investigated the effect of myelin-specific T cells on oligodendrocyte formation at sites of axonal damage in the mouse hippocampal dentate gyrus. Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25{\%} increase in the numbers of oligodendrocytes. In contrast, T cells specific for ovalbumin did not stimulate the formation of new oligodendrocytes. In addition, infiltration of myelin-specific T cells enhanced the sprouting response of calretinergic associational/commissural fibers within the dentate gyrus. These results have implications for the perception of MS pathogenesis because they show that infiltrating myelin-specific T cells can stimulate oligodendrogenesis in the adult central nervous system.",
keywords = "Aging, Animals, Axons, Calcium-Binding Protein, Vitamin D-Dependent, Cell Count, Cell Movement, Cell Proliferation, Cytokines, Dentate Gyrus, Female, Mice, Myelin Proteolipid Protein, Myelin Sheath, Nerve Degeneration, Neurogenesis, Neurons, Afferent, Oligodendroglia, Organ Specificity, Perforant Pathway, RNA, Messenger, T-Lymphocytes",
author = "{Hvilsted Nielsen}, Helle and Henrik Toft-Hansen and Lambertsen, {Kate Lykke} and Trevor Owens and Bente Finsen",
note = "Copyright {\circledC} 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.",
year = "2011",
doi = "10.1016/j.ajpath.2011.06.006",
language = "English",
volume = "179",
pages = "2028--41",
journal = "American Journal of Pathology",
issn = "0002-9440",
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}

Stimulation of adult oligodendrogenesis by myelin-specific T cells. / Hvilsted Nielsen, Helle; Toft-Hansen, Henrik; Lambertsen, Kate Lykke; Owens, Trevor; Finsen, Bente.

In: American Journal of Pathology, Vol. 179, No. 4, 2011, p. 2028-41.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Stimulation of adult oligodendrogenesis by myelin-specific T cells

AU - Hvilsted Nielsen, Helle

AU - Toft-Hansen, Henrik

AU - Lambertsen, Kate Lykke

AU - Owens, Trevor

AU - Finsen, Bente

N1 - Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

PY - 2011

Y1 - 2011

N2 - In multiple sclerosis (MS), myelin-specific T cells are normally associated with destruction of myelin and axonal damage. However, in acute MS plaque, remyelination occurs concurrent with T-cell infiltration, which raises the question of whether T cells might stimulate myelin repair. We investigated the effect of myelin-specific T cells on oligodendrocyte formation at sites of axonal damage in the mouse hippocampal dentate gyrus. Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25% increase in the numbers of oligodendrocytes. In contrast, T cells specific for ovalbumin did not stimulate the formation of new oligodendrocytes. In addition, infiltration of myelin-specific T cells enhanced the sprouting response of calretinergic associational/commissural fibers within the dentate gyrus. These results have implications for the perception of MS pathogenesis because they show that infiltrating myelin-specific T cells can stimulate oligodendrogenesis in the adult central nervous system.

AB - In multiple sclerosis (MS), myelin-specific T cells are normally associated with destruction of myelin and axonal damage. However, in acute MS plaque, remyelination occurs concurrent with T-cell infiltration, which raises the question of whether T cells might stimulate myelin repair. We investigated the effect of myelin-specific T cells on oligodendrocyte formation at sites of axonal damage in the mouse hippocampal dentate gyrus. Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25% increase in the numbers of oligodendrocytes. In contrast, T cells specific for ovalbumin did not stimulate the formation of new oligodendrocytes. In addition, infiltration of myelin-specific T cells enhanced the sprouting response of calretinergic associational/commissural fibers within the dentate gyrus. These results have implications for the perception of MS pathogenesis because they show that infiltrating myelin-specific T cells can stimulate oligodendrogenesis in the adult central nervous system.

KW - Aging

KW - Animals

KW - Axons

KW - Calcium-Binding Protein, Vitamin D-Dependent

KW - Cell Count

KW - Cell Movement

KW - Cell Proliferation

KW - Cytokines

KW - Dentate Gyrus

KW - Female

KW - Mice

KW - Myelin Proteolipid Protein

KW - Myelin Sheath

KW - Nerve Degeneration

KW - Neurogenesis

KW - Neurons, Afferent

KW - Oligodendroglia

KW - Organ Specificity

KW - Perforant Pathway

KW - RNA, Messenger

KW - T-Lymphocytes

U2 - 10.1016/j.ajpath.2011.06.006

DO - 10.1016/j.ajpath.2011.06.006

M3 - Journal article

VL - 179

SP - 2028

EP - 2041

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 4

ER -