TY - JOUR
T1 - Standardised definitions and diagnostic criteria for extranodal extension detected on histopathological examination in head and neck cancer
T2 - Head and Neck Cancer International Group consensus recommendations
AU - Abou-Foul, Ahmad K.
AU - Henson, Christina
AU - Chernock, Rebecca D.
AU - Huang, Shao Hui
AU - Lydiatt, William M.
AU - McDowell, Lachlan
AU - O'Sullivan, Brian
AU - Perez-Ordonez, Bayardo
AU - Robinson, Max
AU - Nankivell, Paul C.
AU - Ruiz-Bravo, Elena
AU - Chiosea, Simion I.
AU - Green, Tina M.
AU - Hunter, Keith D.
AU - Hwang, Jacqueline SG
AU - Koljenovic, Senada
AU - Koppes, Sjors A.
AU - Larsen, Stine R.
AU - Lo, Anthony W.I.
AU - Costes-Martineau, Valérie
AU - Mittal, Neha
AU - Mori, Taisuke
AU - Nagao, Toshitaka
AU - Panayiotides, Ioannis G.
AU - Pinto, Clóvis A.L.
AU - Scheckenbach, Kathrin
AU - Seethala, Raja R.
AU - Ulhøi, Benedicte P.
AU - Vingiani, Andrea
AU - Zhang, Yan
AU - Yom, Sue S.
AU - Mehanna, Hisham
PY - 2024/7
Y1 - 2024/7
N2 - Detection of extranodal extension on histopathology in surgically treated head and neck squamous cell carcinoma indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation, and reporting of histology detected extranodal extension, which has contributed to conflicting evidence in the literature, and likely clinical inconsistency. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts representing 15 national clinical research groups to generate consensus recommendations for histology detected extranodal extension diagnostic criteria. The expert panel strongly agreed on terminology and diagnostic features for histology detected extranodal extension and soft tissue metastasis. Moreover, the panel reached consensus on reporting of histology detected extranodal extension and on nodal sampling. These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a crucial development towards standardised diagnosis and reporting of histology detected extranodal extension, and more accurate data collection and analysis.
AB - Detection of extranodal extension on histopathology in surgically treated head and neck squamous cell carcinoma indicates poor prognosis. However, there is no consensus on the diagnostic criteria, interpretation, and reporting of histology detected extranodal extension, which has contributed to conflicting evidence in the literature, and likely clinical inconsistency. The Head and Neck Cancer International Group conducted a three-round modified Delphi process with a group of 19 international pathology experts representing 15 national clinical research groups to generate consensus recommendations for histology detected extranodal extension diagnostic criteria. The expert panel strongly agreed on terminology and diagnostic features for histology detected extranodal extension and soft tissue metastasis. Moreover, the panel reached consensus on reporting of histology detected extranodal extension and on nodal sampling. These consensus recommendations, endorsed by 19 organisations representing 34 countries, are a crucial development towards standardised diagnosis and reporting of histology detected extranodal extension, and more accurate data collection and analysis.
U2 - 10.1016/S1470-2045(24)00143-8
DO - 10.1016/S1470-2045(24)00143-8
M3 - Journal article
C2 - 38936387
AN - SCOPUS:85196643768
SN - 1470-2045
VL - 25
SP - e286-e296
JO - The Lancet Oncology
JF - The Lancet Oncology
IS - 7
ER -