St. John's wort impairs glucose tolerance by reducing insulin response in healthy men

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalClinical Therapeutics
Volume37
Issue number8 (Supplement)
Pages (from-to)e9-e10
ISSN0149-2918
DOIs
Publication statusPublished - 2015
EventEuropean Association of Clinical Pharmacology and Therapeutics - Madrid, Spain
Duration: 27. Jun 201530. Jun 2015

Conference

ConferenceEuropean Association of Clinical Pharmacology and Therapeutics
CountrySpain
CityMadrid
Period27/06/201530/06/2015

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Hypericum
Insulin
Insulin Resistance
Glucose Tolerance Test
Nonprescription Drugs
Glucose Intolerance
Medicinal Plants
Type 2 Diabetes Mellitus
Serum

Cite this

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title = "St. John's wort impairs glucose tolerance by reducing insulin response in healthy men",
abstract = "The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.",
author = "Stage, {Tore Bjerregaard} and Per Damkier and Christensen, {Mette Marie Hougaard} and Nielsen, {Lene Buch-Krogh} and Kurt H{\o}jlund and Kim Br{\o}sen",
note = "This article is protected by copyright. All rights reserved.",
year = "2015",
doi = "10.1016/j.clinthera.2015.05.037",
language = "English",
volume = "37",
pages = "e9--e10",
journal = "Clinical Therapeutics",
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St. John's wort impairs glucose tolerance by reducing insulin response in healthy men. / Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard; Nielsen, Lene Buch-Krogh; Højlund, Kurt; Brøsen, Kim.

In: Clinical Therapeutics, Vol. 37, No. 8 (Supplement), 2015, p. e9-e10.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - St. John's wort impairs glucose tolerance by reducing insulin response in healthy men

AU - Stage, Tore Bjerregaard

AU - Damkier, Per

AU - Christensen, Mette Marie Hougaard

AU - Nielsen, Lene Buch-Krogh

AU - Højlund, Kurt

AU - Brøsen, Kim

N1 - This article is protected by copyright. All rights reserved.

PY - 2015

Y1 - 2015

N2 - The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.

AB - The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.

U2 - 10.1016/j.clinthera.2015.05.037

DO - 10.1016/j.clinthera.2015.05.037

M3 - Conference abstract in journal

VL - 37

SP - e9-e10

JO - Clinical Therapeutics

JF - Clinical Therapeutics

SN - 0149-2918

IS - 8 (Supplement)

ER -