Abstract
The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Journal | Clinical Therapeutics |
| Volume | 37 |
| Issue number | 8 (Supplement) |
| Pages (from-to) | e9-e10 |
| ISSN | 0149-2918 |
| DOIs | |
| Publication status | Published - 2015 |
| Event | European Association of Clinical Pharmacology and Therapeutics - Madrid, Spain Duration: 27. Jun 2015 → 30. Jun 2015 |
Conference
| Conference | European Association of Clinical Pharmacology and Therapeutics |
|---|---|
| Country | Spain |
| City | Madrid |
| Period | 27/06/2015 → 30/06/2015 |
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St. John's wort impairs glucose tolerance by reducing insulin response in healthy men. / Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard; Nielsen, Lene Buch-Krogh; Højlund, Kurt; Brøsen, Kim.
In: Clinical Therapeutics, Vol. 37, No. 8 (Supplement), 2015, p. e9-e10.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
TY - ABST
T1 - St. John's wort impairs glucose tolerance by reducing insulin response in healthy men
AU - Stage, Tore Bjerregaard
AU - Damkier, Per
AU - Christensen, Mette Marie Hougaard
AU - Nielsen, Lene Buch-Krogh
AU - Højlund, Kurt
AU - Brøsen, Kim
N1 - This article is protected by copyright. All rights reserved.
PY - 2015
Y1 - 2015
N2 - The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.
AB - The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days treatment with St. John's wort and C: At least 6 weeks after the last capsule of St. John's wort was ingested. Plasma glucose, serum insulin and C-peptide levels were measured during an oral glucose tolerance test and used for estimation of area under the concentration-time curve (AUC) as well as and indices of insulin sensitivity and insulin secretion. We found that treatment with St. John's wort increased total and incremental glucose AUC and 2-hr plasma glucose levels. Surprisingly, this effect was sustained and even further increased 6 weeks after the last capsule of St. John's wort was taken. No effect on indices of insulin sensitivity was seen, but indices of insulin secretion were reduced even after adjustment for insulin sensitivity. In conclusion, this study indicates that long-term treatment with St. John's wort may impair glucose tolerance by reducing insulin secretion in young, healthy men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved.
U2 - 10.1016/j.clinthera.2015.05.037
DO - 10.1016/j.clinthera.2015.05.037
M3 - Conference abstract in journal
VL - 37
SP - e9-e10
JO - Clinical Therapeutics
JF - Clinical Therapeutics
SN - 0149-2918
IS - 8 (Supplement)
ER -