Splice switching oligonucleotides pseudoexons

Brage Andresen; Thomas Doktor; Lise Holm; Ulrika Simone Spangsberg Petersen; Gitte Bruun

Splice switching oligonucleotides pseudoexons

Brage Andresen (Inventor), Thomas Doktor (Inventor), Lise Holm (Inventor), Ulrika Simone Spangsberg Petersen (Inventor), Gitte Bruun (Inventor)

Research output: Patent

Abstract

The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

Original language	English
IPC	A61K31/7088, C12N15/11,C12N15/113
Patent number	AU2022213196 (A1)
Country/Territory	Denmark
Priority date	26/01/2021
Priority number	WO2022EP51790
Publication status	Published - 10. Aug 2023

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title = "Splice switching oligonucleotides pseudoexons",

abstract = "The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.",

author = "Brage Andresen and Thomas Doktor and Lise Holm and Petersen, {Ulrika Simone Spangsberg} and Gitte Bruun",

year = "2023",

month = aug,

day = "10",

language = "English",

type = "Patent",

note = "AU2022213196 (A1); A61K31/7088, C12N15/11,C12N15/113",

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TY - PAT

T1 - Splice switching oligonucleotides pseudoexons

AU - Andresen, Brage

AU - Doktor, Thomas

AU - Holm, Lise

AU - Petersen, Ulrika Simone Spangsberg

AU - Bruun, Gitte

PY - 2023/8/10

Y1 - 2023/8/10

N2 - The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

AB - The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5' splice site of said pseudoexon. The invention also relates to SSO obtained by said method and uses thereof.

M3 - Patent

M1 - AU2022213196 (A1)

ER -

Splice switching oligonucleotides pseudoexons

Abstract

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