SP-D as a biomarker for COPD in the Lebanese population

Zeina Akiki, Dalia Fakih, Rania Jounblat, Souleima Chamat, Mirna Waked, Grith Lykke Sørensen, Rachel Nadif, Pascale Salameh

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Abstract

Background: Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population. Objective: The validity of serum SP-D as a biomarker for COPD, in comparison with C-reactive protein (CRP) and fibrinogen was investigated. Associations between SP-D levels and lung function tests and the value of combining SP-D and the Diagnosis Score of COPD (DS-COPD) for COPD diagnosis were also evaluated. Methods:90 COPD patients and 452 controls were recruited. Standardized questionnaires, lung function tests, COPD diagnosis (GOLD 2013), and blood collection were performed. Serum SP-D and CRP, and plasma fibrinogen levels were measured by ELISA. Associations between biological markers with lung function parameters and COPD were estimated by spearman correlation and logistic regression models respectively. Results: Median serum SP-D levels for COPD patients were 1510 ng/mL (from 986 to 2174 ng/mL). SP-D levels were positively associated with age and pack-years in controls (all p<0.01). SP-D levels above the median value were positively associated with COPD (adjusted OR (aOR)=2.86, 95%CI: 1.37-5.98). Higher DS-COPD values (aOR=1.8, 1.49-2.16) and SP-D levels above the median value (aOR=3.51, 1.21-10.1) were significantly and independently associated with COPD in patients and healthy controls aged 40 years or above. No associations were found between CRP, fibrinogen levels and COPD, or between SP-D levels and lung function tests. Conclusion: SP-D seems to be a more reliable biomarker than CRP or fibrinogen for COPD diagnosis in the Lebanese population. Used with the DSCOPD, the SP-D measure could provide a simple and inexpensive tool for COPD diagnosis.
Original languageEnglish
Publication date1. Sep 2014
Publication statusPublished - 1. Sep 2014

Fingerprint

Pulmonary Surfactant-Associated Protein D
Chronic Obstructive Pulmonary Disease
Population
Respiratory Function Tests
Logistic Models

Cite this

Akiki, Z., Fakih, D., Jounblat, R., Chamat, S., Waked, M., Sørensen, G. L., ... Salameh, P. (2014). SP-D as a biomarker for COPD in the Lebanese population.
Akiki, Zeina ; Fakih, Dalia ; Jounblat, Rania ; Chamat, Souleima ; Waked, Mirna ; Sørensen, Grith Lykke ; Nadif, Rachel ; Salameh, Pascale . / SP-D as a biomarker for COPD in the Lebanese population.
@conference{9ad6a94a4ee748e58ae5076db2874432,
title = "SP-D as a biomarker for COPD in the Lebanese population",
abstract = "Background: Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population. Objective: The validity of serum SP-D as a biomarker for COPD, in comparison with C-reactive protein (CRP) and fibrinogen was investigated. Associations between SP-D levels and lung function tests and the value of combining SP-D and the Diagnosis Score of COPD (DS-COPD) for COPD diagnosis were also evaluated. Methods:90 COPD patients and 452 controls were recruited. Standardized questionnaires, lung function tests, COPD diagnosis (GOLD 2013), and blood collection were performed. Serum SP-D and CRP, and plasma fibrinogen levels were measured by ELISA. Associations between biological markers with lung function parameters and COPD were estimated by spearman correlation and logistic regression models respectively. Results: Median serum SP-D levels for COPD patients were 1510 ng/mL (from 986 to 2174 ng/mL). SP-D levels were positively associated with age and pack-years in controls (all p<0.01). SP-D levels above the median value were positively associated with COPD (adjusted OR (aOR)=2.86, 95{\%}CI: 1.37-5.98). Higher DS-COPD values (aOR=1.8, 1.49-2.16) and SP-D levels above the median value (aOR=3.51, 1.21-10.1) were significantly and independently associated with COPD in patients and healthy controls aged 40 years or above. No associations were found between CRP, fibrinogen levels and COPD, or between SP-D levels and lung function tests. Conclusion: SP-D seems to be a more reliable biomarker than CRP or fibrinogen for COPD diagnosis in the Lebanese population. Used with the DSCOPD, the SP-D measure could provide a simple and inexpensive tool for COPD diagnosis.",
author = "Zeina Akiki and Dalia Fakih and Rania Jounblat and Souleima Chamat and Mirna Waked and S{\o}rensen, {Grith Lykke} and Rachel Nadif and Pascale Salameh",
year = "2014",
month = "9",
day = "1",
language = "English",

}

Akiki, Z, Fakih, D, Jounblat, R, Chamat, S, Waked, M, Sørensen, GL, Nadif, R & Salameh, P 2014, 'SP-D as a biomarker for COPD in the Lebanese population'.

SP-D as a biomarker for COPD in the Lebanese population. / Akiki, Zeina ; Fakih, Dalia; Jounblat, Rania; Chamat, Souleima; Waked, Mirna ; Sørensen, Grith Lykke; Nadif, Rachel ; Salameh, Pascale .

2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

TY - ABST

T1 - SP-D as a biomarker for COPD in the Lebanese population

AU - Akiki, Zeina

AU - Fakih, Dalia

AU - Jounblat, Rania

AU - Chamat, Souleima

AU - Waked, Mirna

AU - Sørensen, Grith Lykke

AU - Nadif, Rachel

AU - Salameh, Pascale

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population. Objective: The validity of serum SP-D as a biomarker for COPD, in comparison with C-reactive protein (CRP) and fibrinogen was investigated. Associations between SP-D levels and lung function tests and the value of combining SP-D and the Diagnosis Score of COPD (DS-COPD) for COPD diagnosis were also evaluated. Methods:90 COPD patients and 452 controls were recruited. Standardized questionnaires, lung function tests, COPD diagnosis (GOLD 2013), and blood collection were performed. Serum SP-D and CRP, and plasma fibrinogen levels were measured by ELISA. Associations between biological markers with lung function parameters and COPD were estimated by spearman correlation and logistic regression models respectively. Results: Median serum SP-D levels for COPD patients were 1510 ng/mL (from 986 to 2174 ng/mL). SP-D levels were positively associated with age and pack-years in controls (all p<0.01). SP-D levels above the median value were positively associated with COPD (adjusted OR (aOR)=2.86, 95%CI: 1.37-5.98). Higher DS-COPD values (aOR=1.8, 1.49-2.16) and SP-D levels above the median value (aOR=3.51, 1.21-10.1) were significantly and independently associated with COPD in patients and healthy controls aged 40 years or above. No associations were found between CRP, fibrinogen levels and COPD, or between SP-D levels and lung function tests. Conclusion: SP-D seems to be a more reliable biomarker than CRP or fibrinogen for COPD diagnosis in the Lebanese population. Used with the DSCOPD, the SP-D measure could provide a simple and inexpensive tool for COPD diagnosis.

AB - Background: Surfactant protein D (SP-D), a promising systemic biomarker of chronic obstructive pulmonary disease (COPD) was never evaluated in the Lebanese population. Objective: The validity of serum SP-D as a biomarker for COPD, in comparison with C-reactive protein (CRP) and fibrinogen was investigated. Associations between SP-D levels and lung function tests and the value of combining SP-D and the Diagnosis Score of COPD (DS-COPD) for COPD diagnosis were also evaluated. Methods:90 COPD patients and 452 controls were recruited. Standardized questionnaires, lung function tests, COPD diagnosis (GOLD 2013), and blood collection were performed. Serum SP-D and CRP, and plasma fibrinogen levels were measured by ELISA. Associations between biological markers with lung function parameters and COPD were estimated by spearman correlation and logistic regression models respectively. Results: Median serum SP-D levels for COPD patients were 1510 ng/mL (from 986 to 2174 ng/mL). SP-D levels were positively associated with age and pack-years in controls (all p<0.01). SP-D levels above the median value were positively associated with COPD (adjusted OR (aOR)=2.86, 95%CI: 1.37-5.98). Higher DS-COPD values (aOR=1.8, 1.49-2.16) and SP-D levels above the median value (aOR=3.51, 1.21-10.1) were significantly and independently associated with COPD in patients and healthy controls aged 40 years or above. No associations were found between CRP, fibrinogen levels and COPD, or between SP-D levels and lung function tests. Conclusion: SP-D seems to be a more reliable biomarker than CRP or fibrinogen for COPD diagnosis in the Lebanese population. Used with the DSCOPD, the SP-D measure could provide a simple and inexpensive tool for COPD diagnosis.

M3 - Conference abstract for conference

ER -

Akiki Z, Fakih D, Jounblat R, Chamat S, Waked M, Sørensen GL et al. SP-D as a biomarker for COPD in the Lebanese population. 2014.