TY - JOUR
T1 - Soluble guanylate cyclase as a direct target for pharmacologic mitigation of chronic kidney disease
AU - Jensen, Mia
AU - Jensen, Boye Lagerbon
PY - 2025/3
Y1 - 2025/3
N2 - In a preclinical rat study, Lichtenberger et al. show that BAY-60-2770, a drug that activates soluble guanylyl cyclase, often rendered inactive by oxidative stress, mitigates kidney inflammation, injury, and fibrosis, likely by vascular effects after ischemia-reperfusion. Kidney perfusion, overall vascular reactivity, and medullary microvascular diameter are improved by the drug at doses that do not alter blood pressure. Soluble guanylyl cyclase is an attractive and potentially unexploited target to halt progression of chronic kidney disease.
AB - In a preclinical rat study, Lichtenberger et al. show that BAY-60-2770, a drug that activates soluble guanylyl cyclase, often rendered inactive by oxidative stress, mitigates kidney inflammation, injury, and fibrosis, likely by vascular effects after ischemia-reperfusion. Kidney perfusion, overall vascular reactivity, and medullary microvascular diameter are improved by the drug at doses that do not alter blood pressure. Soluble guanylyl cyclase is an attractive and potentially unexploited target to halt progression of chronic kidney disease.
U2 - 10.1016/j.kint.2024.12.011
DO - 10.1016/j.kint.2024.12.011
M3 - Comment/debate
SN - 0085-2538
VL - 107
SP - 391
EP - 394
JO - Kidney International
JF - Kidney International
IS - 3
ER -