Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms: A Case Report and Literature Review

Alexander Braathen, Uffe Bødtger

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Abstract
Background: Solitary Fibrous Tumors of the Pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).
Methods: A case report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.
Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and eurogenic theory.
Conclusion: SFTP has many factors associated with development of HPO but all
these resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly.
Original languageEnglish
JournalInternational Journal of Cancer and Oncology
Volume4
Issue number2
Pages (from-to)220-224
ISSN2377-0902
DOIs
Publication statusPublished - 2017

Fingerprint

Lung
Secondary Hypertrophic Osteoarthropathy
Paraneoplastic Syndromes
Hypoglycemia
PubMed
Language
Neoplasms

Keywords

  • Pleura
  • Pleural Neoplasms
  • Imaging
  • Cancer
  • Paraneoplastic Syndromes (PNS)
  • outpatient care
  • Diagnosis
  • pleura biopsy
  • Solitary Fibrous Tumor, Pleural

Cite this

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title = "Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms: A Case Report and Literature Review",
abstract = "AbstractBackground: Solitary Fibrous Tumors of the Pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).Methods: A case report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and eurogenic theory.Conclusion: SFTP has many factors associated with development of HPO but allthese resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly.",
keywords = "Pleura, Pleural Neoplasms, Imaging, Cancer, Paraneoplastic Syndromes (PNS), outpatient care, Diagnosis, pleura biopsy, Solitary Fibrous Tumor, Pleural",
author = "Alexander Braathen and Uffe B{\o}dtger",
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Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms : A Case Report and Literature Review. / Braathen, Alexander; Bødtger, Uffe.

In: International Journal of Cancer and Oncology, Vol. 4, No. 2, 2017, p. 220-224.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Solitary Fibrous Tumour of the Pleura and Paraneoplastic Symptoms

T2 - A Case Report and Literature Review

AU - Braathen, Alexander

AU - Bødtger, Uffe

PY - 2017

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N2 - AbstractBackground: Solitary Fibrous Tumors of the Pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).Methods: A case report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and eurogenic theory.Conclusion: SFTP has many factors associated with development of HPO but allthese resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly.

AB - AbstractBackground: Solitary Fibrous Tumors of the Pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).Methods: A case report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and eurogenic theory.Conclusion: SFTP has many factors associated with development of HPO but allthese resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly.

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KW - Paraneoplastic Syndromes (PNS)

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KW - Diagnosis

KW - pleura biopsy

KW - Solitary Fibrous Tumor, Pleural

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JO - International Journal of Cancer and Oncology

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SN - 2377-0902

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