Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply

Gitte R Hinrichs; Kathrin Weyer; Ulla G Friis; Per Svenningsen; Ida Katrine Lund; Rikke Nielsen; Géraldine Mollet; Corinne Antignac; Claus Bistrup; Boye L Jensen; Henrik Birn

doi:10.1111/apha.13432

Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply

Gitte R Hinrichs, Kathrin Weyer, Ulla G Friis, Per Svenningsen, Ida Katrine Lund, Rikke Nielsen, Géraldine Mollet, Corinne Antignac, Claus Bistrup, Boye L Jensen, Henrik Birn

Research output: Contribution to journal › Comment/debate › Research › peer-review

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Abstract

There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by 2 parallel studies published in Acta Physiologica (1, 2). This has generated an editorial comment (3) which we respond to by this rebuttal. The interest in the nephrotic edema reflects not only the significant negative impact this has on the quality of life, but also the difficulties associated with identifying optimal treatment due to the lack of pathophysiological insight.

Original language	English
Article number	e13432
Journal	Acta Physiologica (Print)
Volume	228
Issue number	4
ISSN	1748-1708
DOIs	https://doi.org/10.1111/apha.13432
Publication status	Published - Apr 2020

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10.1111/apha.13432

Open Access VersionAccepted manuscript, 2.1 MB

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@article{05c31ecf47814a93a3771157d4e3fac4,

title = "Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply",

abstract = "There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by 2 parallel studies published in Acta Physiologica (1, 2). This has generated an editorial comment (3) which we respond to by this rebuttal. The interest in the nephrotic edema reflects not only the significant negative impact this has on the quality of life, but also the difficulties associated with identifying optimal treatment due to the lack of pathophysiological insight.",

author = "Hinrichs, {Gitte R} and Kathrin Weyer and Friis, {Ulla G} and Per Svenningsen and Lund, {Ida Katrine} and Rikke Nielsen and G{\'e}raldine Mollet and Corinne Antignac and Claus Bistrup and Jensen, {Boye L} and Henrik Birn",

note = "{\textcopyright} 2019 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.",

year = "2020",

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Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply. / Hinrichs, Gitte R; Weyer, Kathrin; Friis, Ulla G ; Svenningsen, Per; Lund, Ida Katrine; Nielsen, Rikke; Mollet, Géraldine; Antignac, Corinne; Bistrup, Claus ; Jensen, Boye L; Birn, Henrik.

In: Acta Physiologica (Print), Vol. 228, No. 4, e13432, 04.2020.

Research output: Contribution to journal › Comment/debate › Research › peer-review

TY - JOUR

T1 - Sodium retention by uPA-plasmin-ENaC in nephrotic syndrome-Authors reply

AU - Hinrichs, Gitte R

AU - Weyer, Kathrin

AU - Friis, Ulla G

AU - Svenningsen, Per

AU - Lund, Ida Katrine

AU - Nielsen, Rikke

AU - Mollet, Géraldine

AU - Antignac, Corinne

AU - Bistrup, Claus

AU - Jensen, Boye L

AU - Birn, Henrik

PY - 2020/4

Y1 - 2020/4

N2 - There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by 2 parallel studies published in Acta Physiologica (1, 2). This has generated an editorial comment (3) which we respond to by this rebuttal. The interest in the nephrotic edema reflects not only the significant negative impact this has on the quality of life, but also the difficulties associated with identifying optimal treatment due to the lack of pathophysiological insight.

AB - There is a great interest in exploring the mechanisms of oedema in nephrotic syndrome (NS) as evidenced by 2 parallel studies published in Acta Physiologica (1, 2). This has generated an editorial comment (3) which we respond to by this rebuttal. The interest in the nephrotic edema reflects not only the significant negative impact this has on the quality of life, but also the difficulties associated with identifying optimal treatment due to the lack of pathophysiological insight.

U2 - 10.1111/apha.13432

DO - 10.1111/apha.13432

M3 - Comment/debate

C2 - 31845496

VL - 228

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 4

M1 - e13432

ER -