Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives

P Jest, K E Pedersen, N A Klitgaard, J Rokkedal Nielsen, A Arentoft, Torben Johansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.
Original languageEnglish
JournalActa medica Scandinavica. Supplementum
Volume714
Pages (from-to)75-9
Number of pages5
ISSN0365-463X
Publication statusPublished - 1986

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Homeostasis
Salts
Sodium-Potassium-Exchanging ATPase

Keywords

  • Adult
  • Blood Pressure
  • Diet, Sodium-Restricted
  • Homeostasis
  • Humans
  • Hypertension
  • Lymphocytes
  • Male
  • Middle Aged
  • Potassium
  • Sodium

Cite this

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title = "Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives",
abstract = "Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.",
keywords = "Adult, Blood Pressure, Diet, Sodium-Restricted, Homeostasis, Humans, Hypertension, Lymphocytes, Male, Middle Aged, Potassium, Sodium",
author = "P Jest and Pedersen, {K E} and Klitgaard, {N A} and {Rokkedal Nielsen}, J and A Arentoft and Torben Johansen",
year = "1986",
language = "English",
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pages = "75--9",
journal = "Acta medica Scandinavica. Supplementum",
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Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives. / Jest, P; Pedersen, K E; Klitgaard, N A; Rokkedal Nielsen, J; Arentoft, A; Johansen, Torben.

In: Acta medica Scandinavica. Supplementum, Vol. 714, 1986, p. 75-9.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives

AU - Jest, P

AU - Pedersen, K E

AU - Klitgaard, N A

AU - Rokkedal Nielsen, J

AU - Arentoft, A

AU - Johansen, Torben

PY - 1986

Y1 - 1986

N2 - Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.

AB - Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.

KW - Adult

KW - Blood Pressure

KW - Diet, Sodium-Restricted

KW - Homeostasis

KW - Humans

KW - Hypertension

KW - Lymphocytes

KW - Male

KW - Middle Aged

KW - Potassium

KW - Sodium

M3 - Journal article

VL - 714

SP - 75

EP - 79

JO - Acta medica Scandinavica. Supplementum

JF - Acta medica Scandinavica. Supplementum

SN - 0365-463X

ER -