Sodium homeostasis in lymphocytes and blood pressure alterations before and during salt restriction in normotensives and in essential hypertensives

P Jest, K E Pedersen, N A Klitgaard, J Rokkedal Nielsen, A Arentoft, Torben Johansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Blood pressure, lymphocytic sodium content and sodium efflux were studied in hypertensive and normotensive subjects during salt restriction. Diastolic blood pressure decreased significantly in both groups. In essential hypertension the initial high lymphocyte sodium content decreased during salt depletion with a simultaneous decrease in absolute sodium efflux probably due to primary changes in sodium influx. Conversely intralymphocytic sodium content increased in normotensive subjects, which may be caused by an inhibition of the sodium, potassium pump. Our findings indicate that autoregulatory mechanisms with regard to lymphocyte sodium metabolism differs between hypertensive and normotensive subjects.
Original languageEnglish
JournalActa medica Scandinavica. Supplementum
Volume714
Pages (from-to)75-9
Number of pages5
ISSN0365-463X
Publication statusPublished - 1986

Keywords

  • Adult
  • Blood Pressure
  • Diet, Sodium-Restricted
  • Homeostasis
  • Humans
  • Hypertension
  • Lymphocytes
  • Male
  • Middle Aged
  • Potassium
  • Sodium

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