SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction

Anne Yaël Nossent; Jakob Liebe Hansen; Carine Doggen; Paul H A Quax; Søren P Sheikh; Frits R Rosendaal

doi:10.1038/ajh.2011.92

SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction

Anne Yaël Nossent
, Jakob Liebe Hansen
, Carine Doggen
, Paul H A Quax
, Søren P Sheikh
, Frits R Rosendaal

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction.

Original language	English
Journal	American Journal of Hypertension
Volume	24
Issue number	9
Pages (from-to)	999-1006
Number of pages	8
ISSN	0895-7061
DOIs	https://doi.org/10.1038/ajh.2011.92
Publication status	Published - 2011

Keywords

3' Untranslated Regions
Binding Sites
Blood Pressure
Factor VIII
Humans
MicroRNAs
Myocardial Infarction
Polymorphism, Single Nucleotide
Receptor, Bradykinin B2
Receptors, Thromboxane A2, Prostaglandin H2
Receptors, Vasopressin
Renin-Angiotensin System
von Willebrand Factor

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10.1038/ajh.2011.92

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title = "SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction",

abstract = "We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction.",

keywords = "3' Untranslated Regions, Binding Sites, Blood Pressure, Factor VIII, Humans, MicroRNAs, Myocardial Infarction, Polymorphism, Single Nucleotide, Receptor, Bradykinin B2, Receptors, Thromboxane A2, Prostaglandin H2, Receptors, Vasopressin, Renin-Angiotensin System, von Willebrand Factor",

author = "Nossent, \{Anne Ya{\"e}l\} and Hansen, \{Jakob Liebe\} and Carine Doggen and Quax, \{Paul H A\} and Sheikh, \{S{\o}ren P\} and Rosendaal, \{Frits R\}",

year = "2011",

doi = "10.1038/ajh.2011.92",

language = "English",

volume = "24",

pages = "999--1006",

journal = "American Journal of Hypertension",

issn = "0895-7061",

publisher = "Oxford University Press",

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TY - JOUR

T1 - SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction

AU - Nossent, Anne Yaël

AU - Hansen, Jakob Liebe

AU - Doggen, Carine

AU - Quax, Paul H A

AU - Sheikh, Søren P

AU - Rosendaal, Frits R

PY - 2011

Y1 - 2011

N2 - We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction.

AB - We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction.

KW - 3' Untranslated Regions

KW - Binding Sites

KW - Blood Pressure

KW - Factor VIII

KW - Humans

KW - MicroRNAs

KW - Myocardial Infarction

KW - Polymorphism, Single Nucleotide

KW - Receptor, Bradykinin B2

KW - Receptors, Thromboxane A2, Prostaglandin H2

KW - Receptors, Vasopressin

KW - Renin-Angiotensin System

KW - von Willebrand Factor

U2 - 10.1038/ajh.2011.92

DO - 10.1038/ajh.2011.92

M3 - Journal article

C2 - 21677697

SN - 0895-7061

VL - 24

SP - 999

EP - 1006

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 9

ER -

SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction

Abstract

Keywords

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