The manufacturing industry is seeing an increase in demand for more custom-made, low-volume production. This type of production is rarely automated and is to a large extent still performed manually. To keep up with the competition and market demands, manufacturers will have to undertake the effort to automate such manufacturing processes. However, automating low-volume production is no small feat as the solution should be adaptable and future proof to unexpected changes in customers’ demands. In this paper, we propose a reconfigurable robot workcell aimed at automating low-volume production. The developed workcell can adapt to the changes in manufacturing processes by employing a number of passive, reconfigurable hardware elements, supported by the ROS-based, modular control software. To further facilitate and expedite the setup process, we integrated intuitive, user-friendly robot programming methods with the available hardware. The system was evaluated by implementing five production processes from different manufacturing industries.