Small RNAs in major foodborne pathogens: from novel regulatory activities to future applications

Mette Thorsing, Patricia Isabel Teixeira dos Santos, Birgitte H. Kallipolitis

Research output: Contribution to journalJournal articleResearchpeer-review

166 Downloads (Pure)


Small regulatory RNAs (sRNAs) are involved in post-transcriptional control of important cellular processes and contribute to the success of a pathogen. Here, we use studies primarily selected from Salmonella enterica and Listeria monocytogenes to illustrate the current status of sRNA biology in important foodborne pathogens. We discuss how the regulatory activities of sRNAs can be affected by base pairing RNAs known as ‘sponge RNAs’, or by RNA-binding proteins, such as the newly discovered sRNA chaperone ProQ. Furthermore, we highlight recent findings for sRNAs with regulatory roles during infection, some of which are present in multiple copies, designated ‘sibling sRNAs’. Importantly, knowledge on sRNA-mediated regulation can be exploited for biotechnological applications, such as in generating gene knockdowns to promote desired traits.

Original languageEnglish
JournalCurrent Opinion in Biotechnology
Pages (from-to)120-128
Publication statusPublished - Feb 2018


  • Bacteria/genetics
  • Biological Assay
  • Biotechnology
  • Food Microbiology
  • Gene Expression Regulation, Bacterial
  • RNA, Bacterial/metabolism


Dive into the research topics of 'Small RNAs in major foodborne pathogens: from novel regulatory activities to future applications'. Together they form a unique fingerprint.

Cite this