Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation

Basem Abdallah, Abbas Jafari, Walid Zaher, Weimin Qiu, Moustapha Kassem

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.
Original languageEnglish
JournalBone
Volume70
Pages (from-to)28-36
Number of pages9
ISSN8756-3282
DOIs
Publication statusPublished - Jan 2015

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