Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial

Mads J Andersen, Mads Ersbøll, Anna Axelsson, Finn Gustafsson, Christian Hassager, Lars Køber, Barry A Borlaug, Søren Boesgaard, Lene T Skovgaard, Jacob E Møller

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Diastolic dysfunction is frequently seen after myocardial infarction and is characterized by a disproportionate increase in filling pressure during exercise to maintain stroke volume. We hypothesized that sildenafil would reduce filling pressure during exercise in patients with diastolic dysfunction after myocardial infarction.
Original languageEnglish
JournalCirkulation
Volume127
Issue number11
Pages (from-to)1200-1208
ISSN1103-2855
DOIs
Publication statusPublished - 2013

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Exercise
Sildenafil Citrate

Keywords

  • Aged
  • Blood Pressure
  • Diastole
  • Double-Blind Method
  • Exercise
  • Female
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Phosphodiesterase 5 Inhibitors
  • Piperazines
  • Pulmonary Wedge Pressure
  • Purines
  • Rest
  • Stroke Volume
  • Sulfones
  • Vascular Resistance

Cite this

Andersen, Mads J ; Ersbøll, Mads ; Axelsson, Anna ; Gustafsson, Finn ; Hassager, Christian ; Køber, Lars ; Borlaug, Barry A ; Boesgaard, Søren ; Skovgaard, Lene T ; Møller, Jacob E. / Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction : the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial. In: Cirkulation. 2013 ; Vol. 127, No. 11. pp. 1200-1208.
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abstract = "Diastolic dysfunction is frequently seen after myocardial infarction and is characterized by a disproportionate increase in filling pressure during exercise to maintain stroke volume. We hypothesized that sildenafil would reduce filling pressure during exercise in patients with diastolic dysfunction after myocardial infarction.",
keywords = "Aged, Blood Pressure, Diastole, Double-Blind Method, Exercise, Female, Hemodynamics, Humans, Male, Middle Aged, Myocardial Infarction, Phosphodiesterase 5 Inhibitors, Piperazines, Pulmonary Wedge Pressure, Purines, Rest, Stroke Volume, Sulfones, Vascular Resistance",
author = "Andersen, {Mads J} and Mads Ersb{\o}ll and Anna Axelsson and Finn Gustafsson and Christian Hassager and Lars K{\o}ber and Borlaug, {Barry A} and S{\o}ren Boesgaard and Skovgaard, {Lene T} and M{\o}ller, {Jacob E}",
year = "2013",
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volume = "127",
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journal = "Cirkulation",
issn = "1103-2855",
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Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction : the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial. / Andersen, Mads J; Ersbøll, Mads; Axelsson, Anna; Gustafsson, Finn; Hassager, Christian; Køber, Lars; Borlaug, Barry A; Boesgaard, Søren; Skovgaard, Lene T; Møller, Jacob E.

In: Cirkulation, Vol. 127, No. 11, 2013, p. 1200-1208.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction

T2 - the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial

AU - Andersen, Mads J

AU - Ersbøll, Mads

AU - Axelsson, Anna

AU - Gustafsson, Finn

AU - Hassager, Christian

AU - Køber, Lars

AU - Borlaug, Barry A

AU - Boesgaard, Søren

AU - Skovgaard, Lene T

AU - Møller, Jacob E

PY - 2013

Y1 - 2013

N2 - Diastolic dysfunction is frequently seen after myocardial infarction and is characterized by a disproportionate increase in filling pressure during exercise to maintain stroke volume. We hypothesized that sildenafil would reduce filling pressure during exercise in patients with diastolic dysfunction after myocardial infarction.

AB - Diastolic dysfunction is frequently seen after myocardial infarction and is characterized by a disproportionate increase in filling pressure during exercise to maintain stroke volume. We hypothesized that sildenafil would reduce filling pressure during exercise in patients with diastolic dysfunction after myocardial infarction.

KW - Aged

KW - Blood Pressure

KW - Diastole

KW - Double-Blind Method

KW - Exercise

KW - Female

KW - Hemodynamics

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Phosphodiesterase 5 Inhibitors

KW - Piperazines

KW - Pulmonary Wedge Pressure

KW - Purines

KW - Rest

KW - Stroke Volume

KW - Sulfones

KW - Vascular Resistance

U2 - 10.1161/CIRCULATIONAHA.112.000056

DO - 10.1161/CIRCULATIONAHA.112.000056

M3 - Journal article

C2 - 23406672

VL - 127

SP - 1200

EP - 1208

JO - Cirkulation

JF - Cirkulation

SN - 1103-2855

IS - 11

ER -