Abstract
The latest revision of the bone remodeling process has now established that it involves three successive phases: (1) a short initial resorption phase by primary osteoclasts, (2) a longer reversal-resorption phase with intermixed osteoblastic reversal cells and secondary osteoclasts, and (3) a subsequent formation phase. The present chapter focuses on: (1) the histological characteristics of remodeling sites within the reversal-resorption phase, (2) a new definition of the eroded surfaces largely reflecting the reversal-resorption phase, (3) the histological characteristics of eroded surfaces arrested within the reversal-resorption phase, (4) the contribution of a prolonged reversal-resorption phase to the bone loss with age, utilizing cortical porosity as a measure of the bone loss.
| Original language | English |
|---|---|
| Title of host publication | Osteoporotic Fracture and Systemic Skeletal Disorders : Mechanism, Assessment, and Treatment |
| Editors | Hideaki E. Takahashi, David B. Burr, Noriaki Yamamoto |
| Number of pages | 10 |
| Publisher | Springer |
| Publication date | 2022 |
| Pages | 101-110 |
| Chapter | 7 |
| ISBN (Print) | 9789811656125, 9789811656156 |
| ISBN (Electronic) | 9789811656132 |
| DOIs | |
| Publication status | Published - 2022 |
Keywords
- Aging
- Basic multicellular unit
- BMU balance
- Bone formation
- Bone loss
- Bone marrow envelope
- Bone remodeling cycle
- Bone resorption
- Canopy
- Cortical porosity
- Cortical thinning
- Coupling
- Osteoblasts
- Osteoclasts
- Osteoporosis
- Remodeling-based bone formation
- Reversal phase