Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2

Laura Sarkisian, L. Saaby, T. S. Poulsen, O. Gerke, A. C. Diederichsen, Nikolaj Jangaard, S. Hosbond, K. Thygesen, H. Mickley

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value
Original languageEnglish
Article numberA13297
JournalCirculation
Volume132
ISSN0009-7322
Publication statusPublished - 2015
EventAmerican Heart Association Congress - Orlando, United States
Duration: 7. Nov 201511. Nov 2015

Conference

ConferenceAmerican Heart Association Congress
CountryUnited States
CityOrlando
Period07/11/201511/11/2015

Cite this

Sarkisian, Laura ; Saaby, L. ; Poulsen, T. S. ; Gerke, O. ; Diederichsen, A. C. ; Jangaard, Nikolaj ; Hosbond, S. ; Thygesen, K. ; Mickley, H. / Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2. In: Circulation. 2015 ; Vol. 132.
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abstract = "Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9{\%} (33/360) in type 1 MI, 24{\%} (28/119) in type 2 MI, and 21{\%} (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value",
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author = "Laura Sarkisian and L. Saaby and Poulsen, {T. S.} and O. Gerke and Diederichsen, {A. C.} and Nikolaj Jangaard and S. Hosbond and K. Thygesen and H. Mickley",
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Sarkisian, L, Saaby, L, Poulsen, TS, Gerke, O, Diederichsen, AC, Jangaard, N, Hosbond, S, Thygesen, K & Mickley, H 2015, 'Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2', Circulation, vol. 132, A13297.

Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2. / Sarkisian, Laura; Saaby, L.; Poulsen, T. S.; Gerke, O.; Diederichsen, A. C.; Jangaard, Nikolaj; Hosbond, S.; Thygesen, K.; Mickley, H.

In: Circulation, Vol. 132, A13297, 2015.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2

AU - Sarkisian, Laura

AU - Saaby, L.

AU - Poulsen, T. S.

AU - Gerke, O.

AU - Diederichsen, A. C.

AU - Jangaard, Nikolaj

AU - Hosbond, S.

AU - Thygesen, K.

AU - Mickley, H.

PY - 2015

Y1 - 2015

N2 - Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value

AB - Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value

KW - heart infarction heart muscle injury patient mortality resuscitation human medical society follow up Kaplan Meier method prognosis heart muscle ischemia hazard ratio regression analysis diagnosis log rank test hospital patient statistical significance tro

M3 - Conference abstract in journal

VL - 132

JO - Circulation

JF - Circulation

SN - 0009-7322

M1 - A13297

ER -