Shift work is associated with reduced heart rate variability among men but not women

Gerben Hulsegge*, Nidhi Gupta, Karin I. Proper, Natasja van Lobenstein, Wilhelmina IJzelenberg, David M. Hallman, Andreas Holtermann, Allard J. van der Beek

*Corresponding author for this work

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Abstract

Background: Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases. Objective: We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers. Methods: The study included 665 blue-collar workers aged 18–68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function. Multiple linear regression analyses were used to investigate differences in HRV between day and shift workers. Results: Shift workers had no significantly different HRV parameters than day workers, except for a lower VLF (B: 0.21; 95% CI: −0.36–0.05). The lower VLF was only present among non-night shift workers (p < 0.05) and not among night shift workers (p > 0.05). Results differed significantly by gender (p for interaction < 0.10): among men, shift work was negatively associated with RMSSD (B: −7.83; 95% CI: −14.28–1.38), SDNN (B: −7.0; 95% CI: −12.27–1.78), VLF (B: −0.27; 95% CI: −0.46–0.09) and Total Power (B: −0.61; 95% CI: −1.20–0.03), while among women, shift work was only associated with the LF/HF ratio (B: −0.29; 95% CI: −0.54–0.03). Conclusion: Shift work was particularly associated with lower HRV during sleep among men. This indicates that shift work causes imbalance in the autonomic nervous system among men, which might increase their risk of cardiovascular diseases.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume258
Pages (from-to)109-114
ISSN0167-5273
DOIs
Publication statusPublished - 1. May 2018

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Circadian Rhythm
Occupations
Linear Models
Cohort Studies
Regression Analysis
Power (Psychology)

Keywords

  • Autonomic nervous system
  • Cardiovascular diseases
  • Heart rate variability
  • Night shift
  • Shift work
  • Shift Work Schedule/adverse effects
  • Circadian Rhythm/physiology
  • Heart Rate/physiology
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Male
  • Sex Characteristics
  • Denmark/epidemiology
  • Adult
  • Female
  • Work Schedule Tolerance/physiology
  • Cardiovascular Diseases/diagnosis
  • Cohort Studies

Cite this

Hulsegge, G., Gupta, N., Proper, K. I., van Lobenstein, N., IJzelenberg, W., Hallman, D. M., ... van der Beek, A. J. (2018). Shift work is associated with reduced heart rate variability among men but not women. International Journal of Cardiology, 258, 109-114. https://doi.org/10.1016/j.ijcard.2018.01.089
Hulsegge, Gerben ; Gupta, Nidhi ; Proper, Karin I. ; van Lobenstein, Natasja ; IJzelenberg, Wilhelmina ; Hallman, David M. ; Holtermann, Andreas ; van der Beek, Allard J. / Shift work is associated with reduced heart rate variability among men but not women. In: International Journal of Cardiology. 2018 ; Vol. 258. pp. 109-114.
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title = "Shift work is associated with reduced heart rate variability among men but not women",
abstract = "Background: Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases. Objective: We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers. Methods: The study included 665 blue-collar workers aged 18–68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function. Multiple linear regression analyses were used to investigate differences in HRV between day and shift workers. Results: Shift workers had no significantly different HRV parameters than day workers, except for a lower VLF (B: 0.21; 95{\%} CI: −0.36–0.05). The lower VLF was only present among non-night shift workers (p < 0.05) and not among night shift workers (p > 0.05). Results differed significantly by gender (p for interaction < 0.10): among men, shift work was negatively associated with RMSSD (B: −7.83; 95{\%} CI: −14.28–1.38), SDNN (B: −7.0; 95{\%} CI: −12.27–1.78), VLF (B: −0.27; 95{\%} CI: −0.46–0.09) and Total Power (B: −0.61; 95{\%} CI: −1.20–0.03), while among women, shift work was only associated with the LF/HF ratio (B: −0.29; 95{\%} CI: −0.54–0.03). Conclusion: Shift work was particularly associated with lower HRV during sleep among men. This indicates that shift work causes imbalance in the autonomic nervous system among men, which might increase their risk of cardiovascular diseases.",
keywords = "Autonomic nervous system, Cardiovascular diseases, Heart rate variability, Night shift, Shift work, Shift Work Schedule/adverse effects, Circadian Rhythm/physiology, Heart Rate/physiology, Cross-Sectional Studies, Humans, Middle Aged, Male, Sex Characteristics, Denmark/epidemiology, Adult, Female, Work Schedule Tolerance/physiology, Cardiovascular Diseases/diagnosis, Cohort Studies",
author = "Gerben Hulsegge and Nidhi Gupta and Proper, {Karin I.} and {van Lobenstein}, Natasja and Wilhelmina IJzelenberg and Hallman, {David M.} and Andreas Holtermann and {van der Beek}, {Allard J.}",
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Hulsegge, G, Gupta, N, Proper, KI, van Lobenstein, N, IJzelenberg, W, Hallman, DM, Holtermann, A & van der Beek, AJ 2018, 'Shift work is associated with reduced heart rate variability among men but not women', International Journal of Cardiology, vol. 258, pp. 109-114. https://doi.org/10.1016/j.ijcard.2018.01.089

Shift work is associated with reduced heart rate variability among men but not women. / Hulsegge, Gerben; Gupta, Nidhi; Proper, Karin I.; van Lobenstein, Natasja; IJzelenberg, Wilhelmina; Hallman, David M.; Holtermann, Andreas; van der Beek, Allard J.

In: International Journal of Cardiology, Vol. 258, 01.05.2018, p. 109-114.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Shift work is associated with reduced heart rate variability among men but not women

AU - Hulsegge, Gerben

AU - Gupta, Nidhi

AU - Proper, Karin I.

AU - van Lobenstein, Natasja

AU - IJzelenberg, Wilhelmina

AU - Hallman, David M.

AU - Holtermann, Andreas

AU - van der Beek, Allard J.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases. Objective: We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers. Methods: The study included 665 blue-collar workers aged 18–68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function. Multiple linear regression analyses were used to investigate differences in HRV between day and shift workers. Results: Shift workers had no significantly different HRV parameters than day workers, except for a lower VLF (B: 0.21; 95% CI: −0.36–0.05). The lower VLF was only present among non-night shift workers (p < 0.05) and not among night shift workers (p > 0.05). Results differed significantly by gender (p for interaction < 0.10): among men, shift work was negatively associated with RMSSD (B: −7.83; 95% CI: −14.28–1.38), SDNN (B: −7.0; 95% CI: −12.27–1.78), VLF (B: −0.27; 95% CI: −0.46–0.09) and Total Power (B: −0.61; 95% CI: −1.20–0.03), while among women, shift work was only associated with the LF/HF ratio (B: −0.29; 95% CI: −0.54–0.03). Conclusion: Shift work was particularly associated with lower HRV during sleep among men. This indicates that shift work causes imbalance in the autonomic nervous system among men, which might increase their risk of cardiovascular diseases.

AB - Background: Imbalance in the autonomic nervous system due to a disrupted circadian rhythm may be a cause of shift work-related cardiovascular diseases. Objective: We aimed to determine the association between shift work and cardiac autonomic activity in blue-collar workers. Methods: The study included 665 blue-collar workers aged 18–68 years in different occupations from two Danish cohort studies. Time and frequency domain parameters of heart rate variability (HRV) were measured during sleep using the Actiheart monitor, and used as markers of cardiac autonomic function. Multiple linear regression analyses were used to investigate differences in HRV between day and shift workers. Results: Shift workers had no significantly different HRV parameters than day workers, except for a lower VLF (B: 0.21; 95% CI: −0.36–0.05). The lower VLF was only present among non-night shift workers (p < 0.05) and not among night shift workers (p > 0.05). Results differed significantly by gender (p for interaction < 0.10): among men, shift work was negatively associated with RMSSD (B: −7.83; 95% CI: −14.28–1.38), SDNN (B: −7.0; 95% CI: −12.27–1.78), VLF (B: −0.27; 95% CI: −0.46–0.09) and Total Power (B: −0.61; 95% CI: −1.20–0.03), while among women, shift work was only associated with the LF/HF ratio (B: −0.29; 95% CI: −0.54–0.03). Conclusion: Shift work was particularly associated with lower HRV during sleep among men. This indicates that shift work causes imbalance in the autonomic nervous system among men, which might increase their risk of cardiovascular diseases.

KW - Autonomic nervous system

KW - Cardiovascular diseases

KW - Heart rate variability

KW - Night shift

KW - Shift work

KW - Shift Work Schedule/adverse effects

KW - Circadian Rhythm/physiology

KW - Heart Rate/physiology

KW - Cross-Sectional Studies

KW - Humans

KW - Middle Aged

KW - Male

KW - Sex Characteristics

KW - Denmark/epidemiology

KW - Adult

KW - Female

KW - Work Schedule Tolerance/physiology

KW - Cardiovascular Diseases/diagnosis

KW - Cohort Studies

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DO - 10.1016/j.ijcard.2018.01.089

M3 - Journal article

C2 - 29433969

AN - SCOPUS:85041530029

VL - 258

SP - 109

EP - 114

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

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Hulsegge G, Gupta N, Proper KI, van Lobenstein N, IJzelenberg W, Hallman DM et al. Shift work is associated with reduced heart rate variability among men but not women. International Journal of Cardiology. 2018 May 1;258:109-114. https://doi.org/10.1016/j.ijcard.2018.01.089