Sex difference in fibrin clot lysability

association with coronary plaque composition

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Introduction: Fibrin clot lysability is associated with development of cardiovascular disease (CVD). We evaluated sex-differences in fibrin clot lysability and the association with coronary plaque composition determined by computed tomography angiography (CTA). Methods: Middle-aged citizens without known CVD were randomly selected from a national registry. A coronary CTA assessed volumes of calcified-, non-calcified-, low-density non-calcified-, and total- plaque using a validated plaque quantification software. A non-enhanced cardiac CT scan assessed the Agatston score. Fibrin structure properties were determined using turbidimetric methods. Plasma concentrations of C-reactive protein and fibrinogen were assessed. Results: 138 individuals (71 women) participated. Men more frequently had coronary plaques compared to women, P < 0.05. Coronary plaque features were comparable between men and women, P > 0.05. Women with total plaque volume > 0 mm 3 had lower fibrin clot lysability compared to women with total plaque volume = 0 mm 3 , adjusted difference [95% confidence interval] 10.28 [1.42–19.15], P = 0.02, and a fibrinogen-dependent lower fibrin clot lysability compared to men with and without coronary plaques, 6.82 [−2.67–16.31], P = 0.16, and 8.73 [−0.43–17.89], P = 0.06, respectively. Fibrinogen correlated with all the coronary plaque features (correlation coefficient r = 0.42–0.57) only in women with total plaque volume > 0 mm 3 , all P < 0.01. Conclusion: Asymptomatic women with coronary plaques assessed by coronary CTA have reduced fibrin clot lysability compared to both women without coronary plaques and men, suggesting a sex-dependent link between coronary atherosclerosis and fibrin clot lysability.

Original languageEnglish
JournalThrombosis Research
Volume174
Pages (from-to)129-136
ISSN0049-3848
DOIs
Publication statusPublished - Feb 2019

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Sex Characteristics
Registries
Coronary Artery Disease
Confidence Intervals
Computed Tomography Angiography

Keywords

  • Cardiovascular disease
  • Coronary plaque composition
  • Fibrin clot lysability
  • Sex-difference

Cite this

@article{6eb0703334a24d859a05c68a31fa488f,
title = "Sex difference in fibrin clot lysability: association with coronary plaque composition",
abstract = "Introduction: Fibrin clot lysability is associated with development of cardiovascular disease (CVD). We evaluated sex-differences in fibrin clot lysability and the association with coronary plaque composition determined by computed tomography angiography (CTA). Methods: Middle-aged citizens without known CVD were randomly selected from a national registry. A coronary CTA assessed volumes of calcified-, non-calcified-, low-density non-calcified-, and total- plaque using a validated plaque quantification software. A non-enhanced cardiac CT scan assessed the Agatston score. Fibrin structure properties were determined using turbidimetric methods. Plasma concentrations of C-reactive protein and fibrinogen were assessed. Results: 138 individuals (71 women) participated. Men more frequently had coronary plaques compared to women, P < 0.05. Coronary plaque features were comparable between men and women, P > 0.05. Women with total plaque volume > 0 mm 3 had lower fibrin clot lysability compared to women with total plaque volume = 0 mm 3 , adjusted difference [95{\%} confidence interval] 10.28 [1.42–19.15], P = 0.02, and a fibrinogen-dependent lower fibrin clot lysability compared to men with and without coronary plaques, 6.82 [−2.67–16.31], P = 0.16, and 8.73 [−0.43–17.89], P = 0.06, respectively. Fibrinogen correlated with all the coronary plaque features (correlation coefficient r = 0.42–0.57) only in women with total plaque volume > 0 mm 3 , all P < 0.01. Conclusion: Asymptomatic women with coronary plaques assessed by coronary CTA have reduced fibrin clot lysability compared to both women without coronary plaques and men, suggesting a sex-dependent link between coronary atherosclerosis and fibrin clot lysability.",
keywords = "Cardiovascular disease, Coronary plaque composition, Fibrin clot lysability, Sex-difference",
author = "Ramshanker Ramanathan and Gram, {J{\o}rgen Brodersen} and Sidelmann, {Johannes Jakobsen} and Damini Dey and Kusk, {Martin Weber} and N{\o}rgaard, {Bjarne L.} and Sand, {Niels Peter}",
year = "2019",
month = "2",
doi = "10.1016/j.thromres.2018.12.020",
language = "English",
volume = "174",
pages = "129--136",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Pergamon Press",

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Sex difference in fibrin clot lysability : association with coronary plaque composition. / Ramanathan, Ramshanker ; Gram, Jørgen Brodersen; Sidelmann, Johannes Jakobsen; Dey, Damini; Kusk, Martin Weber; Nørgaard, Bjarne L.; Sand, Niels Peter.

In: Thrombosis Research, Vol. 174, 02.2019, p. 129-136.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Sex difference in fibrin clot lysability

T2 - association with coronary plaque composition

AU - Ramanathan, Ramshanker

AU - Gram, Jørgen Brodersen

AU - Sidelmann, Johannes Jakobsen

AU - Dey, Damini

AU - Kusk, Martin Weber

AU - Nørgaard, Bjarne L.

AU - Sand, Niels Peter

PY - 2019/2

Y1 - 2019/2

N2 - Introduction: Fibrin clot lysability is associated with development of cardiovascular disease (CVD). We evaluated sex-differences in fibrin clot lysability and the association with coronary plaque composition determined by computed tomography angiography (CTA). Methods: Middle-aged citizens without known CVD were randomly selected from a national registry. A coronary CTA assessed volumes of calcified-, non-calcified-, low-density non-calcified-, and total- plaque using a validated plaque quantification software. A non-enhanced cardiac CT scan assessed the Agatston score. Fibrin structure properties were determined using turbidimetric methods. Plasma concentrations of C-reactive protein and fibrinogen were assessed. Results: 138 individuals (71 women) participated. Men more frequently had coronary plaques compared to women, P < 0.05. Coronary plaque features were comparable between men and women, P > 0.05. Women with total plaque volume > 0 mm 3 had lower fibrin clot lysability compared to women with total plaque volume = 0 mm 3 , adjusted difference [95% confidence interval] 10.28 [1.42–19.15], P = 0.02, and a fibrinogen-dependent lower fibrin clot lysability compared to men with and without coronary plaques, 6.82 [−2.67–16.31], P = 0.16, and 8.73 [−0.43–17.89], P = 0.06, respectively. Fibrinogen correlated with all the coronary plaque features (correlation coefficient r = 0.42–0.57) only in women with total plaque volume > 0 mm 3 , all P < 0.01. Conclusion: Asymptomatic women with coronary plaques assessed by coronary CTA have reduced fibrin clot lysability compared to both women without coronary plaques and men, suggesting a sex-dependent link between coronary atherosclerosis and fibrin clot lysability.

AB - Introduction: Fibrin clot lysability is associated with development of cardiovascular disease (CVD). We evaluated sex-differences in fibrin clot lysability and the association with coronary plaque composition determined by computed tomography angiography (CTA). Methods: Middle-aged citizens without known CVD were randomly selected from a national registry. A coronary CTA assessed volumes of calcified-, non-calcified-, low-density non-calcified-, and total- plaque using a validated plaque quantification software. A non-enhanced cardiac CT scan assessed the Agatston score. Fibrin structure properties were determined using turbidimetric methods. Plasma concentrations of C-reactive protein and fibrinogen were assessed. Results: 138 individuals (71 women) participated. Men more frequently had coronary plaques compared to women, P < 0.05. Coronary plaque features were comparable between men and women, P > 0.05. Women with total plaque volume > 0 mm 3 had lower fibrin clot lysability compared to women with total plaque volume = 0 mm 3 , adjusted difference [95% confidence interval] 10.28 [1.42–19.15], P = 0.02, and a fibrinogen-dependent lower fibrin clot lysability compared to men with and without coronary plaques, 6.82 [−2.67–16.31], P = 0.16, and 8.73 [−0.43–17.89], P = 0.06, respectively. Fibrinogen correlated with all the coronary plaque features (correlation coefficient r = 0.42–0.57) only in women with total plaque volume > 0 mm 3 , all P < 0.01. Conclusion: Asymptomatic women with coronary plaques assessed by coronary CTA have reduced fibrin clot lysability compared to both women without coronary plaques and men, suggesting a sex-dependent link between coronary atherosclerosis and fibrin clot lysability.

KW - Cardiovascular disease

KW - Coronary plaque composition

KW - Fibrin clot lysability

KW - Sex-difference

U2 - 10.1016/j.thromres.2018.12.020

DO - 10.1016/j.thromres.2018.12.020

M3 - Journal article

VL - 174

SP - 129

EP - 136

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

ER -