Abstract

Background: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). Methods: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years. CAC was determined by the Agatston (Ag) score both at baseline and at follow-up. Based on the changes in Ag, the population was divided into two groups: ΔAg = 0 U or ΔAg > 0 U. Fibrin clot analyses were based on turbidimetric methods. Results: At baseline, 116 women and 97 men were included; 84 women and 79 men completed the 5-year follow-up (77%). Independently of covariates, women with ΔAg > 0 had reduced mean (SD) fibrin lysability at follow-up, 40.2% (15.9), both in comparison to baseline, 47.8% (20.4), p = 0.001, to women with ΔAg = 0 U, 51.2% (24.5), p = 0.028, and to men with ΔAg > 0 U, 54.4% (21.0), p = 0.002. Conclusions: Fibrin clot lysability changes over time with considerable sex differences. Women with progression of CAC have reduced fibrin clot lysability compared to men, indicating a sex-specific association between morphological vessel wall changes and fibrin clot lysability.

Original languageEnglish
Article number9
JournalBiology of Sex Differences
Volume9
Number of pages7
ISSN2042-6410
DOIs
Publication statusPublished - 13. Feb 2018

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Sex Characteristics
Disease
morbidity
medication
incidence
Registries
citizen
Incidence
experience
Population
Group

Keywords

  • Cardiovascular disease
  • Coronary artery calcification
  • Fibrin clot lysability
  • Sex difference
  • Coronary Artery Disease/physiopathology
  • Humans
  • Middle Aged
  • Male
  • Coronary Vessels/physiopathology
  • Sex Characteristics
  • Fibrinolysis
  • Female
  • Fibrin/physiology
  • Vascular Calcification/physiopathology

Cite this

@article{2b427cf203bc46198c6aca727e743ab7,
title = "Sex difference in clot lysability and association to coronary artery calcification",
abstract = "Background: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). Methods: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years. CAC was determined by the Agatston (Ag) score both at baseline and at follow-up. Based on the changes in Ag, the population was divided into two groups: ΔAg = 0 U or ΔAg > 0 U. Fibrin clot analyses were based on turbidimetric methods. Results: At baseline, 116 women and 97 men were included; 84 women and 79 men completed the 5-year follow-up (77{\%}). Independently of covariates, women with ΔAg > 0 had reduced mean (SD) fibrin lysability at follow-up, 40.2{\%} (15.9), both in comparison to baseline, 47.8{\%} (20.4), p = 0.001, to women with ΔAg = 0 U, 51.2{\%} (24.5), p = 0.028, and to men with ΔAg > 0 U, 54.4{\%} (21.0), p = 0.002. Conclusions: Fibrin clot lysability changes over time with considerable sex differences. Women with progression of CAC have reduced fibrin clot lysability compared to men, indicating a sex-specific association between morphological vessel wall changes and fibrin clot lysability.",
keywords = "Cardiovascular disease, Coronary artery calcification, Fibrin clot lysability, Sex difference, Coronary Artery Disease/physiopathology, Humans, Middle Aged, Male, Coronary Vessels/physiopathology, Sex Characteristics, Fibrinolysis, Female, Fibrin/physiology, Vascular Calcification/physiopathology",
author = "Ramshanker Ramanathan and {R{\o}nnow Sand}, {Niels Peter} and Sidelmann, {Johannes Jakobsen} and N{\o}rgaard, {Bjarne Linde} and Gram, {J{\o}rgen Brodersen}",
year = "2018",
month = "2",
day = "13",
doi = "10.1186/s13293-018-0168-8",
language = "English",
volume = "9",
journal = "Biology of Sex Differences",
issn = "2042-6410",
publisher = "BioMed Central",

}

Sex difference in clot lysability and association to coronary artery calcification. / Ramanathan, Ramshanker ; Rønnow Sand, Niels Peter; Sidelmann, Johannes Jakobsen; Nørgaard, Bjarne Linde; Gram, Jørgen Brodersen.

In: Biology of Sex Differences, Vol. 9, 9, 13.02.2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Sex difference in clot lysability and association to coronary artery calcification

AU - Ramanathan, Ramshanker

AU - Rønnow Sand, Niels Peter

AU - Sidelmann, Johannes Jakobsen

AU - Nørgaard, Bjarne Linde

AU - Gram, Jørgen Brodersen

PY - 2018/2/13

Y1 - 2018/2/13

N2 - Background: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). Methods: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years. CAC was determined by the Agatston (Ag) score both at baseline and at follow-up. Based on the changes in Ag, the population was divided into two groups: ΔAg = 0 U or ΔAg > 0 U. Fibrin clot analyses were based on turbidimetric methods. Results: At baseline, 116 women and 97 men were included; 84 women and 79 men completed the 5-year follow-up (77%). Independently of covariates, women with ΔAg > 0 had reduced mean (SD) fibrin lysability at follow-up, 40.2% (15.9), both in comparison to baseline, 47.8% (20.4), p = 0.001, to women with ΔAg = 0 U, 51.2% (24.5), p = 0.028, and to men with ΔAg > 0 U, 54.4% (21.0), p = 0.002. Conclusions: Fibrin clot lysability changes over time with considerable sex differences. Women with progression of CAC have reduced fibrin clot lysability compared to men, indicating a sex-specific association between morphological vessel wall changes and fibrin clot lysability.

AB - Background: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). Methods: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years. CAC was determined by the Agatston (Ag) score both at baseline and at follow-up. Based on the changes in Ag, the population was divided into two groups: ΔAg = 0 U or ΔAg > 0 U. Fibrin clot analyses were based on turbidimetric methods. Results: At baseline, 116 women and 97 men were included; 84 women and 79 men completed the 5-year follow-up (77%). Independently of covariates, women with ΔAg > 0 had reduced mean (SD) fibrin lysability at follow-up, 40.2% (15.9), both in comparison to baseline, 47.8% (20.4), p = 0.001, to women with ΔAg = 0 U, 51.2% (24.5), p = 0.028, and to men with ΔAg > 0 U, 54.4% (21.0), p = 0.002. Conclusions: Fibrin clot lysability changes over time with considerable sex differences. Women with progression of CAC have reduced fibrin clot lysability compared to men, indicating a sex-specific association between morphological vessel wall changes and fibrin clot lysability.

KW - Cardiovascular disease

KW - Coronary artery calcification

KW - Fibrin clot lysability

KW - Sex difference

KW - Coronary Artery Disease/physiopathology

KW - Humans

KW - Middle Aged

KW - Male

KW - Coronary Vessels/physiopathology

KW - Sex Characteristics

KW - Fibrinolysis

KW - Female

KW - Fibrin/physiology

KW - Vascular Calcification/physiopathology

U2 - 10.1186/s13293-018-0168-8

DO - 10.1186/s13293-018-0168-8

M3 - Journal article

C2 - 29439739

VL - 9

JO - Biology of Sex Differences

JF - Biology of Sex Differences

SN - 2042-6410

M1 - 9

ER -