Sex and gender in inflammatory bowel disease outcomes and research

Vibeke Andersen; Jessica Pingel; Heidi Lynge Søfelt; Zainab Hikmat; Mads Johansson; Vera Slyk Pedersen; Benthe Bertelsen; Anne Carlsson; Marie Lindh; Edda Svavarsdóttir; Dirk Repsilber; Maiken Thyregod Joergensen; Robin Christensen; Anja Fejrskov; Johannes David Füchtbauer; Jens Kjeldsen; Michael Dam Jensen; Claus Aalykke; Martin Rejler; Marte Lie Høivik; Loa Davidsdottir; Marie Carlson; Jonas Halfvarson; Heidi Holt Zachariassen; Liv Baisner Petersen; Eva Sophia Myers

doi:10.1016/S2468-1253(24)00159-6

Sex and gender in inflammatory bowel disease outcomes and research

Vibeke Andersen^*, Jessica Pingel, Heidi Lynge Søfelt, Zainab Hikmat, Mads Johansson, Vera Slyk Pedersen, Benthe Bertelsen, Anne Carlsson, Marie Lindh, Edda Svavarsdóttir, Dirk Repsilber, Maiken Thyregod Joergensen, Robin Christensen, Anja Fejrskov, Johannes David Füchtbauer, Jens Kjeldsen, Michael Dam Jensen, Claus Aalykke, Martin Rejler, Marte Lie HøivikLoa Davidsdottir, Marie Carlson, Jonas Halfvarson, Heidi Holt Zachariassen, Liv Baisner Petersen, Eva Sophia Myers

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, and sex and gender experts reviewed current literature on the effect of sex and gender dimensions on IBD outcomes. The team also investigated the role that stakeholders have in advancing sex-based and gender-based IBD knowledge, as comprehensive studies are scarce. Acknowledging and integrating sex and gender into the organisation and content of research (eg, study design, participant recruitment, data analysis, data interpretation, data dissemination, and impact evaluation) could enhance the validity, relevance, and applicability of research. Such gendered innovation has potential for advancing personalised medicine and improving the quality of life for people with IBD.

Original language	English
Journal	The Lancet Gastroenterology & Hepatology
Volume	9
Issue number	11
Pages (from-to)	1041-1051
ISSN	2468-1253
DOIs	https://doi.org/10.1016/S2468-1253(24)00159-6
Publication status	Published - Nov 2024

Bibliographical note

Keywords

Humans
Inflammatory Bowel Diseases/psychology
Sex Factors
Female
Male
Quality of Life
Biomedical Research
Research Design

Documents & Links

10.1016/S2468-1253(24)00159-6

Cite this

Andersen, V., Pingel, J., Søfelt, H. L., Hikmat, Z., Johansson, M., Pedersen, V. S., Bertelsen, B., Carlsson, A., Lindh, M., Svavarsdóttir, E., Repsilber, D., Joergensen, M. T., Christensen, R., Fejrskov, A., Füchtbauer, J. D., Kjeldsen, J., Jensen, M. D., Aalykke, C., Rejler, M., ... Myers, E. S. (2024). Sex and gender in inflammatory bowel disease outcomes and research. The Lancet Gastroenterology & Hepatology, 9(11), 1041-1051. https://doi.org/10.1016/S2468-1253(24)00159-6

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title = "Sex and gender in inflammatory bowel disease outcomes and research",

abstract = "Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, and sex and gender experts reviewed current literature on the effect of sex and gender dimensions on IBD outcomes. The team also investigated the role that stakeholders have in advancing sex-based and gender-based IBD knowledge, as comprehensive studies are scarce. Acknowledging and integrating sex and gender into the organisation and content of research (eg, study design, participant recruitment, data analysis, data interpretation, data dissemination, and impact evaluation) could enhance the validity, relevance, and applicability of research. Such gendered innovation has potential for advancing personalised medicine and improving the quality of life for people with IBD.",

keywords = "Humans, Inflammatory Bowel Diseases/psychology, Sex Factors, Female, Male, Quality of Life, Biomedical Research, Research Design",

author = "Vibeke Andersen and Jessica Pingel and S{\o}felt, {Heidi Lynge} and Zainab Hikmat and Mads Johansson and Pedersen, {Vera Slyk} and Benthe Bertelsen and Anne Carlsson and Marie Lindh and Edda Svavarsd{\'o}ttir and Dirk Repsilber and Joergensen, {Maiken Thyregod} and Robin Christensen and Anja Fejrskov and F{\"u}chtbauer, {Johannes David} and Jens Kjeldsen and Jensen, {Michael Dam} and Claus Aalykke and Martin Rejler and H{\o}ivik, {Marte Lie} and Loa Davidsdottir and Marie Carlson and Jonas Halfvarson and Zachariassen, {Heidi Holt} and Petersen, {Liv Baisner} and Myers, {Eva Sophia}",

year = "2024",

month = nov,

doi = "10.1016/S2468-1253(24)00159-6",

language = "English",

volume = "9",

pages = "1041--1051",

journal = "The Lancet Gastroenterology & Hepatology",

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Andersen, V , Pingel, J, Søfelt, HL, Hikmat, Z, Johansson, M, Pedersen, VS, Bertelsen, B, Carlsson, A, Lindh, M, Svavarsdóttir, E, Repsilber, D, Joergensen, MT, Christensen, R , Fejrskov, A , Füchtbauer, JD , Kjeldsen, J , Jensen, MD , Aalykke, C, Rejler, M, Høivik, ML, Davidsdottir, L, Carlson, M, Halfvarson, J, Zachariassen, HH, Petersen, LB & Myers, ES 2024, 'Sex and gender in inflammatory bowel disease outcomes and research', The Lancet Gastroenterology & Hepatology, vol. 9, no. 11, pp. 1041-1051. https://doi.org/10.1016/S2468-1253(24)00159-6

TY - JOUR

T1 - Sex and gender in inflammatory bowel disease outcomes and research

AU - Andersen, Vibeke

AU - Pingel, Jessica

AU - Søfelt, Heidi Lynge

AU - Hikmat, Zainab

AU - Johansson, Mads

AU - Pedersen, Vera Slyk

AU - Bertelsen, Benthe

AU - Carlsson, Anne

AU - Lindh, Marie

AU - Svavarsdóttir, Edda

AU - Repsilber, Dirk

AU - Joergensen, Maiken Thyregod

AU - Christensen, Robin

AU - Fejrskov, Anja

AU - Füchtbauer, Johannes David

AU - Kjeldsen, Jens

AU - Jensen, Michael Dam

AU - Aalykke, Claus

AU - Rejler, Martin

AU - Høivik, Marte Lie

AU - Davidsdottir, Loa

AU - Carlson, Marie

AU - Halfvarson, Jonas

AU - Zachariassen, Heidi Holt

AU - Petersen, Liv Baisner

AU - Myers, Eva Sophia

PY - 2024/11

Y1 - 2024/11

N2 - Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, and sex and gender experts reviewed current literature on the effect of sex and gender dimensions on IBD outcomes. The team also investigated the role that stakeholders have in advancing sex-based and gender-based IBD knowledge, as comprehensive studies are scarce. Acknowledging and integrating sex and gender into the organisation and content of research (eg, study design, participant recruitment, data analysis, data interpretation, data dissemination, and impact evaluation) could enhance the validity, relevance, and applicability of research. Such gendered innovation has potential for advancing personalised medicine and improving the quality of life for people with IBD.

AB - Extensive patient heterogeneity is a challenge in the management of inflammatory bowel disease (IBD). Sex and gender, as well as the interaction of sex and gender with other social identities, referred to as intersectionality, contribute to this heterogeneity and might affect IBD outcomes. An interdisciplinary team of clinicians, researchers, patients, and sex and gender experts reviewed current literature on the effect of sex and gender dimensions on IBD outcomes. The team also investigated the role that stakeholders have in advancing sex-based and gender-based IBD knowledge, as comprehensive studies are scarce. Acknowledging and integrating sex and gender into the organisation and content of research (eg, study design, participant recruitment, data analysis, data interpretation, data dissemination, and impact evaluation) could enhance the validity, relevance, and applicability of research. Such gendered innovation has potential for advancing personalised medicine and improving the quality of life for people with IBD.

KW - Humans

KW - Inflammatory Bowel Diseases/psychology

KW - Sex Factors

KW - Female

KW - Male

KW - Quality of Life

KW - Biomedical Research

KW - Research Design

U2 - 10.1016/S2468-1253(24)00159-6

DO - 10.1016/S2468-1253(24)00159-6

M3 - Journal article

C2 - 39395438

SN - 2468-1253

VL - 9

SP - 1041

EP - 1051

JO - The Lancet Gastroenterology & Hepatology

JF - The Lancet Gastroenterology & Hepatology

IS - 11

ER -

Sex and gender in inflammatory bowel disease outcomes and research

Abstract

Bibliographical note

Keywords

Documents & Links

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Cite this