TY - JOUR
T1 - Sex- and Age Group-Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus
AU - Nasser, Mohamad I.
AU - Kvist, Annika Vestergaard
AU - Vestergaard, Peter
AU - Eastell, Richard
AU - Burden, Andrea M.
AU - Frost, Morten
N1 - Funding Information:
PV reports consulting fees from Novo Nordisk AS. MF reports research grants from Novo Nordisk Foundation; chairmanship of the Expert Committee on treatment of rare bone diseases of the Danish Medicines Council; consulting fees from Novo Nordisk AS; and receipt of drug and placebo free of charge from Novo Nordisk AS for an investigator‐initiated trial. The professorship of AB was partially endowed by the ETH Foundation and PharmaSuisse; however, there was no connection to the current study. RE receives consultancy funding from Immunodiagnostic Systems, Sandoz, Samsung, Haoma Medica, CL Bio, Biocon, Takeda, meeting presentations for Pharmacosmos, Alexion, and Amgen, and grant funding from Roche, Pharmacosmos, and Alexion. MN and AK have no potential conflicts of interest to declare.
Funding Information:
This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 860898.
Funding Information:
This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska‐Curie grant agreement no. 860898.
PY - 2023/11
Y1 - 2023/11
N2 - The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fracture incidence rates (IRs) in men and women with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) in Denmark between 1997 and 2017. We identified men and women aged 18+ years who sustained a fracture (excluding skull and facial fractures) between 1997 and 2017 using the Danish National Patient Registry. We calculated sex-specific IRs of fractures per 10,000 person-years separately in persons with T1D, T2D, or without diabetes. Furthermore, we compared median IRs of the first 5 years (1997–2002) to the median IRs of the last 5 years (2012–2017). We identified 1,235,628 persons with fractures including 4863 (43.6% women) with T1D, 65,366 (57.5% women) with T2D, and 1,165,399 (54.1% women) without diabetes. The median IRs of fractures declined 20.2%, 19.9%, and 7.8% in men with T1D, T2D, and without diabetes, respectively (p-trend <0.05). The median IRs decreased 6.4% in women with T1D (p-trend = 0.35) and 25.6% in women with T2D (p-trend <0.05) but increased 2.3% in women without diabetes (p-trend = 0.08). Fracture IRs decreased in men with both diabetes types and only in women with T2D, highlighting the need for further attention behind the stable trend observed in women with T1D.
AB - The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fracture incidence rates (IRs) in men and women with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) in Denmark between 1997 and 2017. We identified men and women aged 18+ years who sustained a fracture (excluding skull and facial fractures) between 1997 and 2017 using the Danish National Patient Registry. We calculated sex-specific IRs of fractures per 10,000 person-years separately in persons with T1D, T2D, or without diabetes. Furthermore, we compared median IRs of the first 5 years (1997–2002) to the median IRs of the last 5 years (2012–2017). We identified 1,235,628 persons with fractures including 4863 (43.6% women) with T1D, 65,366 (57.5% women) with T2D, and 1,165,399 (54.1% women) without diabetes. The median IRs of fractures declined 20.2%, 19.9%, and 7.8% in men with T1D, T2D, and without diabetes, respectively (p-trend <0.05). The median IRs decreased 6.4% in women with T1D (p-trend = 0.35) and 25.6% in women with T2D (p-trend <0.05) but increased 2.3% in women without diabetes (p-trend = 0.08). Fracture IRs decreased in men with both diabetes types and only in women with T2D, highlighting the need for further attention behind the stable trend observed in women with T1D.
KW - FRACTURES
KW - INCIDENCE
KW - TRENDS
KW - TYPE 1 DIABETES MELLITUS
KW - TYPE 2 DIABETES MELLITUS
U2 - 10.1002/jbm4.10836
DO - 10.1002/jbm4.10836
M3 - Journal article
C2 - 38025040
AN - SCOPUS:85175085870
SN - 2473-4039
VL - 7
JO - JBMR Plus
JF - JBMR Plus
IS - 11
M1 - e10836
ER -