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Severely compromised supply of patch test allergens in Europe hampers adequate diagnosis of occupational and non-occupational contact allergy. A European Society of Contact Dermatitis (ESCD), European Academy of Allergy and Clinical Immunology (EAACI), European Academy of Dermatology and Venereology (EADV) task forces ‘Contact Dermatitis’ and ‘Occupational Skin Disease’ position paper

  • Swen Malte John*
  • , Andreas Bonertz
  • , Julia Zimmer
  • , Olivier Aerts
  • , Andrea Bauer
  • , Maria Bova
  • , Richard Brans
  • , Stefano Del Giacco
  • , Heinrich Dickel
  • , Monica Corazza
  • , Marie Noëlle Crépy
  • , Rosella Gallo
  • , Jose Luis Garcia-Abujeta
  • , Ana Maria Giménez-Arnau
  • , Ludger Klimek
  • , Jean Pierre Lepoittevin
  • , Suzana Ljubojević Hadžavdić
  • , Mihaly Matura
  • , Charlotte Gotthard Mortz
  • , Esen Özkaya
  • Maria Pesonen, Nadia Raison-Peyron, Thomas Rustemeyer, Christoph Skudlik, Radoslaw Spiewak, Luca Stingeni, Sari Suomela, Cara Symanzik, James Taylor, Maria Torres, Wolfgang Uter, Ian White, Mark Wilkinson, Vera Mahler, Jeanne Duus Johansen
*Corresponding author for this work
  • Institute for Interdisciplinary Dermatological Prevention and Rehabilitation
  • Paul-Ehrlich-Institut
  • Antwerp University Hospital
  • University Hospital Carl Gustav Carus
  • Ospedale A Cardarelli
  • University of Cagliari
  • Ruhr University Bochum
  • National Institute for Nuclear Physics
  • Hotel-Dieu de France Hospital
  • IRCCS Azienda Ospedaliera Universitaria San Martino IST
  • Marina Baixa Hospital
  • Pompeu Fabra University
  • Center for Rhinology and Allergology
  • University of Strasbourg
  • University Hospital Centre Zagreb
  • Skaraborg Hospital Skövde
  • Istanbul University
  • Finnish Institute of Occupational Health
  • University Hospital of Montpellier
  • University of Amsterdam
  • Jagiellonian University Medical College
  • University of Perugia
  • Case Western Reserve University
  • Hospital Regional Universitario “Carlos Haya,” Cardiology
  • University of Erlangen-Nuremberg, Germany
  • Guys' Hospital
  • Leeds Teaching Hospitals NHS Trust
  • Copenhagen University Hospital

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Patch testing is the only clinically applicable diagnostic method for Type IV allergy. The availability of Type IV patch test (PT) allergens in Europe, however, is currently scarce. This severely compromises adequate diagnostics of contact allergy, leading to serious consequences for the affected patients. Against this background, the European Society of Contact Dermatitis (ESCD) has created a task force (TF) (i) to explore the current availability of PT substances in different member states, (ii) to highlight some of the unique characteristics of Type IV vs. other allergens and (iii) to suggest ways forward to promote and ensure availability of high-quality patch testing substances for the diagnosis of Type IV allergies throughout Europe. The suggestions of the TF on how to improve the availability of PT allergens are supported by the ESCD, the European Academy of Allergy and Clinical Immunology, and the European Academy of Dermatology and Venereology and intend to provide potential means to resolve the present medical crisis.

Original languageEnglish
JournalContact Dermatitis
Volume91
Issue number2
Pages (from-to)91-103
ISSN0105-1873
DOIs
Publication statusPublished - Aug 2024

Keywords

  • allergen provocation test
  • European Pharmacopoeia
  • marketing authorisation
  • patch test
  • regulatory framework
  • skin test allergens
  • Type IV allergy
  • Humans
  • Europe
  • Patch Tests/methods
  • Advisory Committees
  • Societies, Medical
  • Dermatitis, Allergic Contact/diagnosis
  • Allergens/adverse effects
  • Dermatitis, Occupational/diagnosis

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