Severe Bartonella henselae bone infection in a kidney transplanted young man

Heidi Dahl Christensen*, Ann Brinch Madelung, Anne Lerberg Nielsen, Fredrikke Christie Knudtzen

*Corresponding author for this work

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We present a case of a young kidney transplanted man. He was admitted with lymphadenopathy, fluctuating fever and night sweats 2 months after a cat bite. After admission, he developed severe pain around his right hip. An 18 F-fluorodeoxyglucose (FDG)-positron emission tomography/CT revealed intense FDG-uptake in lymph nodes, spleen and bone, suggestive of lymphoma. An extracted lymph node showed confluent granulomas, microabscesses with neutrophils and scattered multinucleated giant cells histologically. The patient had history of latent tuberculosis and proteinase 3 -anti-neutrophil cytoplasmic antibodies associated (PR3-ANCA) vasculitis, making differential diagnostic considerations complicated. Bartonella henselae antibodies was detected in blood and B. henselae DNA in a lymph node. He was started on doxycycline and rifampicin. Due to severe drug interactions with both tacrolimus and increasing morphine doses, rifampicin was changed to azithromycin. He received 12 days of relevant antibiotic treatment and responded well. He was discharged after 16 days with close follow-up and was still in habitual condition 12 months later.

Original languageEnglish
Article numbere247805
JournalBMJ Case Reports
Issue number5
Publication statusPublished - 18. May 2022

Bibliographical note

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  • Bone and joint infections
  • Drug interactions
  • Drugs: infectious diseases
  • Renal medicine
  • Renal transplantation


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