Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination

Rune M Pedersen; Line L Bang; Lone Wulff Madsen; Thomas V Sydenham; Isik S Johansen; Thøger G Jensen; Ulrik S Justesen; Thomas E Andersen

doi:10.3201/eid2806.220503

Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination

Rune M Pedersen, Line L Bang, Lone Wulff Madsen, Thomas V Sydenham, Isik S Johansen, Thøger G Jensen, Ulrik S Justesen, Thomas E Andersen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The SARS-CoV-2 Omicron variant BA.2 sublineage is rapidly replacing earlier Omicron lineages, suggesting BA.2 has increased vaccine evasion properties. We measured neutralization titers of authentic BA.1 and BA.2 isolates in serum samples from persons who received the BNT162b2 booster vaccine. All samples neutralized BA.1 and BA.2 at equal median values.

Original language	English
Journal	Emerging Infectious Diseases
Volume	28
Issue number	6
Pages (from-to)	1274-1275
ISSN	1080-6059
DOIs	https://doi.org/10.3201/eid2806.220503
Publication status	Published - 1. Jun 2022

Keywords

BA.1
BA.2
COVID-19
Denmark
Omicron
SARS
SARS-CoV-2
coronavirus
coronavirus disease
respiratory infections
serum neutralization
severe acute respiratory syndrome coronavirus 2
viruses
zoonoses

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10.3201/eid2806.220503Licence: Other

Open Access VersionFinal published version, 382 KBLicence: Other

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title = "Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination",

abstract = "The SARS-CoV-2 Omicron variant BA.2 sublineage is rapidly replacing earlier Omicron lineages, suggesting BA.2 has increased vaccine evasion properties. We measured neutralization titers of authentic BA.1 and BA.2 isolates in serum samples from persons who received the BNT162b2 booster vaccine. All samples neutralized BA.1 and BA.2 at equal median values.",

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author = "Pedersen, {Rune M} and Bang, {Line L} and Madsen, {Lone Wulff} and Sydenham, {Thomas V} and Johansen, {Isik S} and Jensen, {Th{\o}ger G} and Justesen, {Ulrik S} and Andersen, {Thomas E}",

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doi = "10.3201/eid2806.220503",

language = "English",

volume = "28",

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journal = "Emerging Infectious Diseases",

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T1 - Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination

AU - Pedersen, Rune M

AU - Bang, Line L

AU - Madsen, Lone Wulff

AU - Sydenham, Thomas V

AU - Johansen, Isik S

AU - Jensen, Thøger G

AU - Justesen, Ulrik S

AU - Andersen, Thomas E

PY - 2022/6/1

Y1 - 2022/6/1

N2 - The SARS-CoV-2 Omicron variant BA.2 sublineage is rapidly replacing earlier Omicron lineages, suggesting BA.2 has increased vaccine evasion properties. We measured neutralization titers of authentic BA.1 and BA.2 isolates in serum samples from persons who received the BNT162b2 booster vaccine. All samples neutralized BA.1 and BA.2 at equal median values.

AB - The SARS-CoV-2 Omicron variant BA.2 sublineage is rapidly replacing earlier Omicron lineages, suggesting BA.2 has increased vaccine evasion properties. We measured neutralization titers of authentic BA.1 and BA.2 isolates in serum samples from persons who received the BNT162b2 booster vaccine. All samples neutralized BA.1 and BA.2 at equal median values.

KW - BA.1

KW - BA.2

KW - COVID-19

KW - Denmark

KW - Omicron

KW - SARS

KW - SARS-CoV-2

KW - coronavirus

KW - coronavirus disease

KW - respiratory infections

KW - serum neutralization

KW - severe acute respiratory syndrome coronavirus 2

KW - viruses

KW - zoonoses

U2 - 10.3201/eid2806.220503

DO - 10.3201/eid2806.220503

M3 - Journal article

C2 - 35356875

SN - 1080-6059

VL - 28

SP - 1274

EP - 1275

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -

Serum Neutralization of SARS-CoV-2 Omicron BA.1 and BA.2 after BNT162b2 Booster Vaccination

Abstract

Keywords

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