Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity

Sofus C Larsen, Lars Ängquist, Max Moldovan, Ville Huikari, Sylvain Sebert, Alana Cavadino, Tarunveer Singh Ahluwalia, Tea Skaaby, Allan Linneberg, Lise Lotte N Husemoen, Ulla Toft, Oluf Pedersen, Torben Hansen, Karl-Heinz Herzig, Marjo-Riitta Jarvelin, Chris Power, Elina Hyppönen, Berit L Heitmann, Thorkild I A Sørensen

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Abstract

Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

Original languageEnglish
Article numbere0153611
JournalP L o S One
Volume11
Issue number4
Number of pages18
ISSN1932-6203
DOIs
Publication statusPublished - 2016

Fingerprint

waist circumference
Adiposity
adiposity
Polymorphism
Nucleotides
Weights and Measures
Serum
single nucleotide polymorphism
Single Nucleotide Polymorphism
waist
hips
Linear regression
body weight
body weight changes
Finland
Meta-Analysis
25-hydroxyvitamin D
Linear Models
obesity

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Larsen, S. C., Ängquist, L., Moldovan, M., Huikari, V., Sebert, S., Cavadino, A., ... Sørensen, T. I. A. (2016). Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity. P L o S One, 11(4), [e0153611]. https://doi.org/10.1371/journal.pone.0153611
Larsen, Sofus C ; Ängquist, Lars ; Moldovan, Max ; Huikari, Ville ; Sebert, Sylvain ; Cavadino, Alana ; Singh Ahluwalia, Tarunveer ; Skaaby, Tea ; Linneberg, Allan ; Husemoen, Lise Lotte N ; Toft, Ulla ; Pedersen, Oluf ; Hansen, Torben ; Herzig, Karl-Heinz ; Jarvelin, Marjo-Riitta ; Power, Chris ; Hyppönen, Elina ; Heitmann, Berit L ; Sørensen, Thorkild I A. / Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference : Influence of Genetic Predisposition to Adiposity. In: P L o S One. 2016 ; Vol. 11, No. 4.
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abstract = "Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95{\%} CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95{\%} CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.",
author = "Larsen, {Sofus C} and Lars {\"A}ngquist and Max Moldovan and Ville Huikari and Sylvain Sebert and Alana Cavadino and {Singh Ahluwalia}, Tarunveer and Tea Skaaby and Allan Linneberg and Husemoen, {Lise Lotte N} and Ulla Toft and Oluf Pedersen and Torben Hansen and Karl-Heinz Herzig and Marjo-Riitta Jarvelin and Chris Power and Elina Hypp{\"o}nen and Heitmann, {Berit L} and S{\o}rensen, {Thorkild I A}",
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Larsen, SC, Ängquist, L, Moldovan, M, Huikari, V, Sebert, S, Cavadino, A, Singh Ahluwalia, T, Skaaby, T, Linneberg, A, Husemoen, LLN, Toft, U, Pedersen, O, Hansen, T, Herzig, K-H, Jarvelin, M-R, Power, C, Hyppönen, E, Heitmann, BL & Sørensen, TIA 2016, 'Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity', P L o S One, vol. 11, no. 4, e0153611. https://doi.org/10.1371/journal.pone.0153611

Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference : Influence of Genetic Predisposition to Adiposity. / Larsen, Sofus C; Ängquist, Lars; Moldovan, Max; Huikari, Ville; Sebert, Sylvain; Cavadino, Alana; Singh Ahluwalia, Tarunveer; Skaaby, Tea; Linneberg, Allan; Husemoen, Lise Lotte N; Toft, Ulla; Pedersen, Oluf; Hansen, Torben; Herzig, Karl-Heinz; Jarvelin, Marjo-Riitta; Power, Chris; Hyppönen, Elina; Heitmann, Berit L; Sørensen, Thorkild I A.

In: P L o S One, Vol. 11, No. 4, e0153611, 2016.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference

T2 - Influence of Genetic Predisposition to Adiposity

AU - Larsen, Sofus C

AU - Ängquist, Lars

AU - Moldovan, Max

AU - Huikari, Ville

AU - Sebert, Sylvain

AU - Cavadino, Alana

AU - Singh Ahluwalia, Tarunveer

AU - Skaaby, Tea

AU - Linneberg, Allan

AU - Husemoen, Lise Lotte N

AU - Toft, Ulla

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Herzig, Karl-Heinz

AU - Jarvelin, Marjo-Riitta

AU - Power, Chris

AU - Hyppönen, Elina

AU - Heitmann, Berit L

AU - Sørensen, Thorkild I A

PY - 2016

Y1 - 2016

N2 - Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

AB - Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

U2 - 10.1371/journal.pone.0153611

DO - 10.1371/journal.pone.0153611

M3 - Journal article

C2 - 27077659

VL - 11

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 4

M1 - e0153611

ER -