Serial measurements of N-terminal pro-brain natriuretic peptide after acute ischemic stroke

J K Jensen, H Mickley, S Bak, L Korsholm, S R Kristensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established. METHODS: NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke. RESULTS: NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels > or =615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality. CONCLUSION: NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality.
Original languageEnglish
JournalCerebrovascular Diseases
Volume22
Issue number5-6
Pages (from-to)439-44
ISSN1015-9770
DOIs
Publication statusPublished - 2006

Keywords

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Biological Markers
  • Brain Ischemia
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • ROC Curve
  • Research Design
  • Sensitivity and Specificity
  • Stroke
  • Time Factors

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