Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship With Endurance Walking in the Health, Aging and Body Composition Study

Health, Aging and Body Composition Study

doi:10.1016/j.apmr.2015.08.423

Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship With Endurance Walking in the Health, Aging and Body Composition Study

Health, Aging and Body Composition Study

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objectives To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design Prospective cohort study with 6 years of follow-up. Setting Two university research clinics. Participants Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). Interventions Not applicable. Main Outcome Measures Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. Results In separate, fully adjusted linear mixed models, poor vibration threshold (>130μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0s, 14.4s, and 6.9s slower, respectively; P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. Conclusions Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance - a critical component for remaining independent in the community.

Original language	English
Journal	Archives of Physical Medicine and Rehabilitation
Volume	97
Issue number	1
Pages (from-to)	45-52
ISSN	0003-9993
DOIs	https://doi.org/10.1016/j.apmr.2015.08.423
Publication status	Published - Jan 2016

Bibliographical note

ISI Document Delivery No.: DA7CZ Times Cited: 2 Cited Reference Count: 43 Lange-Maia, Brittney S. Newman, Anne B. Cauley, Jane A. Boudreau, Robert M. Jakicic, John M. Caserotti, Paolo Glynn, Nancy W. Harris, Tamara B. Kritchevsky, Stephen B. Schwartz, Ann V. Satterfield, Suzanne Simonsick, Eleanor M. Vinik, Aaron I. Zivkovic, Sasa Strotmeyer, Elsa S. Cauley, Jane/N-4836-2015; Cauley, Jane/0000-0003-0752-4408; Boudreau, Robert/0000-0003-0162-5187; Strotmeyer, Elsa/0000-0002-4093-6036; Glynn, Nancy/0000-0003-2265-0162 National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, 1-R01-AG 028050]; National Institute of Nursing Research [R01-NR012459]; University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30-AG024827]; National Institutes of Health, National Institute on Aging Supported by the National Institute on Aging (contract nos. N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; grant no. 1-R01-AG 028050), the National Institute of Nursing Research (grant no. R01-NR012459), the University of Pittsburgh Claude D. Pepper Older Americans Independence Center (pilot grant no. P30-AG024827), and in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging. 2 4 W b saunders co-elsevier inc Philadelphia 1532-821x

Keywords

Aged Motor neurons Peripheral nerves Physical endurance Rehabilitation Sensation Walking older-adults diabetes-mellitus gait characteristics quadriceps strength physical-fitness neuropathy mobility falls age disease Rehabilitation Sport Sciences
Sensation
Motor neurons
Walking
Peripheral nerves
Aged
Rehabilitation
Physical endurance
Body Composition
Peroneal Nerve/physiopathology
Prospective Studies
Humans
African Americans
Sensory Receptor Cells/physiology
Male
Aging/physiology
Exercise Test
Walking/physiology
Motor Neurons/physiology
Female
Vibration
Sensory Thresholds
European Continental Ancestry Group
Neural Conduction
Physical Endurance/physiology
Longitudinal Studies

Documents & Links

10.1016/j.apmr.2015.08.423

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696894/pdf/nihms732249.pdf

SDU Link

Check access to the material in SDU Library's search engine

Cite this

@article{e4b31c932d6f4e338c39c524d3e1a4b3,

title = "Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship With Endurance Walking in the Health, Aging and Body Composition Study",

abstract = "Objectives To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design Prospective cohort study with 6 years of follow-up. Setting Two university research clinics. Participants Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2\% men; 38.2\% black) and a subset with longitudinal data (n=1178). Interventions Not applicable. Main Outcome Measures Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. Results In separate, fully adjusted linear mixed models, poor vibration threshold (>130μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0s, 14.4s, and 6.9s slower, respectively; P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. Conclusions Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance - a critical component for remaining independent in the community.",

keywords = "Aged Motor neurons Peripheral nerves Physical endurance Rehabilitation Sensation Walking older-adults diabetes-mellitus gait characteristics quadriceps strength physical-fitness neuropathy mobility falls age disease Rehabilitation Sport Sciences, Sensation, Motor neurons, Walking, Peripheral nerves, Aged, Rehabilitation, Physical endurance, Body Composition, Peroneal Nerve/physiopathology, Prospective Studies, Humans, African Americans, Sensory Receptor Cells/physiology, Male, Aging/physiology, Exercise Test, Walking/physiology, Motor Neurons/physiology, Female, Vibration, Sensory Thresholds, European Continental Ancestry Group, Neural Conduction, Physical Endurance/physiology, Longitudinal Studies",

author = "Lange-Maia, \{B. S.\} and Newman, \{Anne B\} and Cauley, \{J A\} and Boudreau, \{R M\} and Jakicic, \{J. M.\} and P. Caserotti and Glynn, \{Nancy W\} and Harris, \{T. B.\} and Kritchevsky, \{S. B.\} and Schwartz, \{A. V.\} and S. Satterfield and Simonsick, \{E. M.\} and Vinik, \{A. I.\} and Sasa Zivkovic and Strotmeyer, \{E S\} and \{Health, Aging and Body Composition Study\}",

note = "ISI Document Delivery No.: DA7CZ Times Cited: 2 Cited Reference Count: 43 Lange-Maia, Brittney S. Newman, Anne B. Cauley, Jane A. Boudreau, Robert M. Jakicic, John M. Caserotti, Paolo Glynn, Nancy W. Harris, Tamara B. Kritchevsky, Stephen B. Schwartz, Ann V. Satterfield, Suzanne Simonsick, Eleanor M. Vinik, Aaron I. Zivkovic, Sasa Strotmeyer, Elsa S. Cauley, Jane/N-4836-2015; Cauley, Jane/0000-0003-0752-4408; Boudreau, Robert/0000-0003-0162-5187; Strotmeyer, Elsa/0000-0002-4093-6036; Glynn, Nancy/0000-0003-2265-0162 National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, 1-R01-AG 028050]; National Institute of Nursing Research [R01-NR012459]; University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30-AG024827]; National Institutes of Health, National Institute on Aging Supported by the National Institute on Aging (contract nos. N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; grant no. 1-R01-AG 028050), the National Institute of Nursing Research (grant no. R01-NR012459), the University of Pittsburgh Claude D. Pepper Older Americans Independence Center (pilot grant no. P30-AG024827), and in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging. 2 4 W b saunders co-elsevier inc Philadelphia 1532-821x",

year = "2016",

month = jan,

doi = "10.1016/j.apmr.2015.08.423",

language = "English",

volume = "97",

pages = "45--52",

journal = "Archives of Physical Medicine and Rehabilitation",

issn = "0003-9993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship With Endurance Walking in the Health, Aging and Body Composition Study

AU - Lange-Maia, B. S.

AU - Newman, Anne B

AU - Cauley, J A

AU - Boudreau, R M

AU - Jakicic, J. M.

AU - Caserotti, P.

AU - Glynn, Nancy W

AU - Harris, T. B.

AU - Kritchevsky, S. B.

AU - Schwartz, A. V.

AU - Satterfield, S.

AU - Simonsick, E. M.

AU - Vinik, A. I.

AU - Zivkovic, Sasa

AU - Strotmeyer, E S

AU - Health, Aging and Body Composition Study

N1 - ISI Document Delivery No.: DA7CZ Times Cited: 2 Cited Reference Count: 43 Lange-Maia, Brittney S. Newman, Anne B. Cauley, Jane A. Boudreau, Robert M. Jakicic, John M. Caserotti, Paolo Glynn, Nancy W. Harris, Tamara B. Kritchevsky, Stephen B. Schwartz, Ann V. Satterfield, Suzanne Simonsick, Eleanor M. Vinik, Aaron I. Zivkovic, Sasa Strotmeyer, Elsa S. Cauley, Jane/N-4836-2015; Cauley, Jane/0000-0003-0752-4408; Boudreau, Robert/0000-0003-0162-5187; Strotmeyer, Elsa/0000-0002-4093-6036; Glynn, Nancy/0000-0003-2265-0162 National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, 1-R01-AG 028050]; National Institute of Nursing Research [R01-NR012459]; University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30-AG024827]; National Institutes of Health, National Institute on Aging Supported by the National Institute on Aging (contract nos. N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; grant no. 1-R01-AG 028050), the National Institute of Nursing Research (grant no. R01-NR012459), the University of Pittsburgh Claude D. Pepper Older Americans Independence Center (pilot grant no. P30-AG024827), and in part by the Intramural Research Program of the National Institutes of Health, National Institute on Aging. 2 4 W b saunders co-elsevier inc Philadelphia 1532-821x

PY - 2016/1

Y1 - 2016/1

N2 - Objectives To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design Prospective cohort study with 6 years of follow-up. Setting Two university research clinics. Participants Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). Interventions Not applicable. Main Outcome Measures Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. Results In separate, fully adjusted linear mixed models, poor vibration threshold (>130μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0s, 14.4s, and 6.9s slower, respectively; P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. Conclusions Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance - a critical component for remaining independent in the community.

AB - Objectives To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. Design Prospective cohort study with 6 years of follow-up. Setting Two university research clinics. Participants Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). Interventions Not applicable. Main Outcome Measures Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. Results In separate, fully adjusted linear mixed models, poor vibration threshold (>130μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0s, 14.4s, and 6.9s slower, respectively; P<.05 for each). Poor motor amplitude (<1mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. Conclusions Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance - a critical component for remaining independent in the community.

KW - Aged Motor neurons Peripheral nerves Physical endurance Rehabilitation Sensation Walking older-adults diabetes-mellitus gait characteristics quadriceps strength physical-fitness neuropathy mobility falls age disease Rehabilitation Sport Sciences

KW - Sensation

KW - Motor neurons

KW - Walking

KW - Peripheral nerves

KW - Aged

KW - Rehabilitation

KW - Physical endurance

KW - Body Composition

KW - Peroneal Nerve/physiopathology

KW - Prospective Studies

KW - Humans

KW - African Americans

KW - Sensory Receptor Cells/physiology

KW - Male

KW - Aging/physiology

KW - Exercise Test

KW - Walking/physiology

KW - Motor Neurons/physiology

KW - Female

KW - Vibration

KW - Sensory Thresholds

KW - European Continental Ancestry Group

KW - Neural Conduction

KW - Physical Endurance/physiology

KW - Longitudinal Studies

U2 - 10.1016/j.apmr.2015.08.423

DO - 10.1016/j.apmr.2015.08.423

M3 - Journal article

C2 - 26343170

SN - 0003-9993

VL - 97

SP - 45

EP - 52

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

IS - 1

ER -

Sensorimotor Peripheral Nerve Function and the Longitudinal Relationship With Endurance Walking in the Health, Aging and Body Composition Study

Abstract

Bibliographical note

Keywords

Documents & Links

SDU Link

Fingerprint

Cite this