Senescence of skeletal stem cells and their contribution to age-related bone loss

Eva M. Wölfel; Paula Fernandez-Guerra; Mikkel Ørnfeldt Nørgård; Shakespeare Jeromdesella; Pernille Kirkegaard Kjær; Anna Sofie Elkjær; Moustapha Kassem; Florence Figeac

doi:10.1016/j.mad.2024.111976

Senescence of skeletal stem cells and their contribution to age-related bone loss

^*Corresponding author for this work

University of Copenhagen

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Abstract

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

Original language	English
Article number	111976
Journal	Mechanisms of Ageing and Development
Volume	221
ISSN	0047-6374
DOIs	https://doi.org/10.1016/j.mad.2024.111976
Publication status	Published - Oct 2024

Keywords

Age-related bone disease
Cellular senescence
Marrow stromal stem cells
Skeletal stem cells

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10.1016/j.mad.2024.111976Licence: CC BY

Open Access VersionFinal published version, 926 KBLicence: CC BY

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title = "Senescence of skeletal stem cells and their contribution to age-related bone loss",

abstract = "Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.",

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doi = "10.1016/j.mad.2024.111976",

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journal = "Mechanisms of Ageing and Development",

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T1 - Senescence of skeletal stem cells and their contribution to age-related bone loss

AU - Wölfel, Eva M.

AU - Fernandez-Guerra, Paula

AU - Nørgård, Mikkel Ørnfeldt

AU - Jeromdesella, Shakespeare

AU - Kjær, Pernille Kirkegaard

AU - Elkjær, Anna Sofie

AU - Kassem, Moustapha

AU - Figeac, Florence

PY - 2024/10

Y1 - 2024/10

N2 - Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

AB - Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

KW - Age-related bone disease

KW - Cellular senescence

KW - Marrow stromal stem cells

KW - Skeletal stem cells

U2 - 10.1016/j.mad.2024.111976

DO - 10.1016/j.mad.2024.111976

M3 - Journal article

C2 - 39111640

AN - SCOPUS:85201399150

SN - 0047-6374

VL - 221

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

M1 - 111976

ER -

Senescence of skeletal stem cells and their contribution to age-related bone loss

Abstract

Keywords

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