Search, Identification, and Design of Effective Antiviral Drugs Against Pandemic Human Coronaviruses

Tianguang Huang, Lin Sun, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan, Luis Menéndez-Arias

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Recent coronavirus outbreaks of SARS-CoV-1 (2002-2003), MERS-CoV (since 2012), and SARS-CoV-2 (since the end of 2019) are examples of how viruses can damage health care and generate havoc all over the world. Coronavirus can spread quickly from person to person causing high morbidity and mortality. Unfortunately, the antiviral armamentarium is insufficient to fight these infections. In this chapter, we provide a detailed summary of the current situation in the development of drugs directed against pandemic human coronaviruses. Apart from the recently licensed remdesivir, other antiviral agents discussed in this review include molecules targeting viral components (e.g., RNA polymerase inhibitors, entry inhibitors, or protease inhibitors), compounds interfering with virus-host interactions, and drugs identified in large screening assays, effective against coronavirus replication, but with an uncertain mechanism of action.

Original languageEnglish
Title of host publicationAntiviral Drug Discovery and Development
EditorsXinyong Liu, Peng Zhan, Luis Menéndez-Arias, Vasanthanathan Poongavanam
PublisherSpringer
Publication date2021
Pages219-260
ISBN (Print)978-981-16-0269-6, 978-981-16-0266-5
ISBN (Electronic)978-981-16-0267-2
DOIs
Publication statusPublished - 2021
SeriesAdvances in Experimental Medicine and Biology
Volume1322
ISSN0065-2598

Keywords

  • Coronavirus
  • MERS-CoV
  • Remdesivir
  • RNA polymerase
  • SARS-CoV
  • Viral replication
  • COVID-19
  • SARS-CoV-2
  • Pandemics
  • Humans
  • Antiviral Agents/pharmacology
  • Middle East Respiratory Syndrome Coronavirus

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