The comparison of two quantitative measuring devices is often performed with the Limits of Agreement proposed by Bland and Altman in their seminal Lancet paper back in 1986. Sample size considerations were rare for such agreement analyses in the past, but recently several proposals have been made depending on how agreement is to be assessed and the number of replicates to be used. We have summarized recent developments and recommendations in various situations including a distinction between method comparison and observer variability studies. These include current state-of-the-art analysis of and reporting guidelines for agreement studies. General recommendations close the paper.

Original languageEnglish
JournalJournal of Clinical Monitoring and Computing
Issue number5
Pages (from-to)1241-1243
Publication statusPublished - Oct 2022


  • Agreement
  • Bland-Altman analysis
  • Limits of Agreement
  • Repeatability
  • Reproducibility
  • Sample size


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