Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29–59 year olds in Denmark

a cross-sectional analysis

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Abstract

Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

Original languageEnglish
Article number300
JournalB M C Musculoskeletal Disorders
Volume19
Number of pages11
ISSN1471-2474
DOIs
Publication statusPublished - 21. Aug 2018

Fingerprint

Denmark
Hip
Knee
Cross-Sectional Studies
Population
Hip Osteoarthritis
Knee Injuries
Joints
Age Groups
Surveys and Questionnaires
Knee Osteoarthritis
Wounds and Injuries

Keywords

  • Hip
  • Knee
  • Osteoarthritis
  • Pain
  • Prevalence
  • Risk factors
  • Age Factors
  • Humans
  • Middle Aged
  • Osteoarthritis, Knee/diagnosis
  • Male
  • Time Factors
  • Adult
  • Female
  • Knee Joint/physiopathology
  • Surveys and Questionnaires
  • Odds Ratio
  • Osteoarthritis, Hip/diagnosis
  • Arthralgia/diagnosis
  • Cross-Sectional Studies
  • Risk Factors
  • Logistic Models
  • Biomechanical Phenomena
  • Health Surveys
  • Hip Joint/physiopathology
  • Pain Measurement

Cite this

@article{65fe4ee880fc460a8c5b2fa75e7b7adf,
title = "Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29–59 year olds in Denmark: a cross-sectional analysis",
abstract = "Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the {"}Early Detection and Prevention{"} pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27{\%}. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.",
keywords = "Kn{\ae}, Hofte, Smerte, Osteoarthritis, Pr{\ae}valens, Risikofaktorer, Hip, Knee, Osteoarthritis, Pain, Prevalence, Risk factors, Age Factors, Humans, Middle Aged, Osteoarthritis, Knee/diagnosis, Male, Time Factors, Adult, Female, Knee Joint/physiopathology, Surveys and Questionnaires, Odds Ratio, Osteoarthritis, Hip/diagnosis, Arthralgia/diagnosis, Cross-Sectional Studies, Risk Factors, Logistic Models, Biomechanical Phenomena, Health Surveys, Hip Joint/physiopathology, Pain Measurement",
author = "{van Tunen}, Joyce and George Peat and Alessio Bricca and {Bruun Larsen}, Lars and Jens S{\o}ndergaard and Trine Thilsing and Roos, {Ewa M.} and Thorlund, {Jonas Bloch}",
year = "2018",
month = "8",
day = "21",
doi = "10.1186/s12891-018-2183-7",
language = "English",
volume = "19",
journal = "B M C Musculoskeletal Disorders",
issn = "1471-2474",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29–59 year olds in Denmark

T2 - a cross-sectional analysis

AU - van Tunen, Joyce

AU - Peat, George

AU - Bricca, Alessio

AU - Bruun Larsen, Lars

AU - Søndergaard, Jens

AU - Thilsing, Trine

AU - Roos, Ewa M.

AU - Thorlund, Jonas Bloch

PY - 2018/8/21

Y1 - 2018/8/21

N2 - Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

AB - Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

KW - Knæ

KW - Hofte

KW - Smerte

KW - Osteoarthritis

KW - Prævalens

KW - Risikofaktorer

KW - Hip

KW - Knee

KW - Osteoarthritis

KW - Pain

KW - Prevalence

KW - Risk factors

KW - Age Factors

KW - Humans

KW - Middle Aged

KW - Osteoarthritis, Knee/diagnosis

KW - Male

KW - Time Factors

KW - Adult

KW - Female

KW - Knee Joint/physiopathology

KW - Surveys and Questionnaires

KW - Odds Ratio

KW - Osteoarthritis, Hip/diagnosis

KW - Arthralgia/diagnosis

KW - Cross-Sectional Studies

KW - Risk Factors

KW - Logistic Models

KW - Biomechanical Phenomena

KW - Health Surveys

KW - Hip Joint/physiopathology

KW - Pain Measurement

U2 - 10.1186/s12891-018-2183-7

DO - 10.1186/s12891-018-2183-7

M3 - Journal article

VL - 19

JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

SN - 1471-2474

M1 - 300

ER -