Salivary gland ultrasound is associated with the presence of autoantibodies in patients with Sjögren’s syndrome: A Danish single-centre study

Nanna Surlemont Schmidt, Anne Voss, Anna Christine Nilsson, Lene Terslev, Søren Andreas Just, Hanne M. Lindegaard*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

30 Downloads (Pure)

Abstract

Objectives To investigate whether ultrasound findings of major salivary glands are correlated with serological markers, autoantibodies, patient- or doctor-reported disease activity in a Danish cohort of patients with primary Sjögren’s Syndrome (pSS). Methods In all, 49 patients at Odense University Hospital with pSS diagnosed according to the 2002 American-European Consensus Group (AECG) classification criteria were included. Patients were characterized using the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI, score of systemic complications) and EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI), serologic markers, Schirmer’s test and salivary test. Salivary gland ultrasound (SGUS) was performed of the submandibular and parotid glands and scored according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) semi-quantitative scoring system. Results More patients with abnormal SGUS had antinuclear antibodies (ANA) (p = 0.002), anti-Ro52 (p = 0.001), anti-Ro60 (p<0.001), anti-La (p<0.001) and IgM-RF (p<0.001). Titers for ANA (p = 0.02) and anti-Ro52 (p = 0.03) were higher in patients with abnormal SGUS. Twenty-three of the pSS patients had no pathological findings on SGUS. There was no correlation between SGUS severity and ESSDAI- or ESSPRI-scores. Conclusions Abnormal SGUS findings are associated with autoantibodies of high specificity for pSS but not with ESSDAI, ESSPRI or inflammatory markers.

Original languageEnglish
Article numbere0265057
JournalPLOS ONE
Volume17
Issue number12
ISSN1932-6203
DOIs
Publication statusPublished - Dec 2022

Fingerprint

Dive into the research topics of 'Salivary gland ultrasound is associated with the presence of autoantibodies in patients with Sjögren’s syndrome: A Danish single-centre study'. Together they form a unique fingerprint.

Cite this