Salivary gland carcinomas of the larynx

A national study in Denmark

Troels Krogh Nielsen, Kristine Bjørndal, Annelise Krogdahl, Hanne Primdahl, Claus Andrup Kristensen, Elo Verner Andersen, Christian Godballe

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature. METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients were male. The patients were treated with surgery and/or radiotherapy. Three patients had recurrent disease. One died of the primary disease and one died of other causes. Four are alive with no evidence of disease. Merging of actual study group with patients from recent literature resulted in 83 cases. The male vs. female ratio was 2:1, the most common location was the supraglottic region (52%) and the most predominant histological subtypes were adenoid cystic carcinoma (46%), mucoepidermoid carcinoma (35%) and adenocarcinoma NOS (12%). CONCLUSION: Laryngeal salivary gland carcinoma is a rare disease with a male predominance and most often localized in the supraglottic region. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. Recurrences are observed later than ten years after primary treatment and a long follow up time is advocated.
Original languageEnglish
JournalAuris Nasus Larynx
Volume39
Issue number6
Pages (from-to)611-4
Number of pages4
ISSN0385-8146
DOIs
Publication statusPublished - 2012

Fingerprint

Denmark
Larynx
Mucoepidermoid Carcinoma
Registries
Adenoid Cystic Carcinoma
Glandular and Epithelial Neoplasms
Rare Diseases
PubMed
Pathology
Incidence

Cite this

Nielsen, Troels Krogh ; Bjørndal, Kristine ; Krogdahl, Annelise ; Primdahl, Hanne ; Kristensen, Claus Andrup ; Andersen, Elo Verner ; Godballe, Christian. / Salivary gland carcinomas of the larynx : A national study in Denmark. In: Auris Nasus Larynx. 2012 ; Vol. 39, No. 6. pp. 611-4.
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title = "Salivary gland carcinomas of the larynx: A national study in Denmark",
abstract = "OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature. METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients were male. The patients were treated with surgery and/or radiotherapy. Three patients had recurrent disease. One died of the primary disease and one died of other causes. Four are alive with no evidence of disease. Merging of actual study group with patients from recent literature resulted in 83 cases. The male vs. female ratio was 2:1, the most common location was the supraglottic region (52{\%}) and the most predominant histological subtypes were adenoid cystic carcinoma (46{\%}), mucoepidermoid carcinoma (35{\%}) and adenocarcinoma NOS (12{\%}). CONCLUSION: Laryngeal salivary gland carcinoma is a rare disease with a male predominance and most often localized in the supraglottic region. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. Recurrences are observed later than ten years after primary treatment and a long follow up time is advocated.",
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Nielsen, TK, Bjørndal, K, Krogdahl, A, Primdahl, H, Kristensen, CA, Andersen, EV & Godballe, C 2012, 'Salivary gland carcinomas of the larynx: A national study in Denmark', Auris Nasus Larynx, vol. 39, no. 6, pp. 611-4. https://doi.org/10.1016/j.anl.2012.02.003

Salivary gland carcinomas of the larynx : A national study in Denmark. / Nielsen, Troels Krogh; Bjørndal, Kristine; Krogdahl, Annelise; Primdahl, Hanne; Kristensen, Claus Andrup; Andersen, Elo Verner; Godballe, Christian.

In: Auris Nasus Larynx, Vol. 39, No. 6, 2012, p. 611-4.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Salivary gland carcinomas of the larynx

T2 - A national study in Denmark

AU - Nielsen, Troels Krogh

AU - Bjørndal, Kristine

AU - Krogdahl, Annelise

AU - Primdahl, Hanne

AU - Kristensen, Claus Andrup

AU - Andersen, Elo Verner

AU - Godballe, Christian

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature. METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients were male. The patients were treated with surgery and/or radiotherapy. Three patients had recurrent disease. One died of the primary disease and one died of other causes. Four are alive with no evidence of disease. Merging of actual study group with patients from recent literature resulted in 83 cases. The male vs. female ratio was 2:1, the most common location was the supraglottic region (52%) and the most predominant histological subtypes were adenoid cystic carcinoma (46%), mucoepidermoid carcinoma (35%) and adenocarcinoma NOS (12%). CONCLUSION: Laryngeal salivary gland carcinoma is a rare disease with a male predominance and most often localized in the supraglottic region. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. Recurrences are observed later than ten years after primary treatment and a long follow up time is advocated.

AB - OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature. METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients were male. The patients were treated with surgery and/or radiotherapy. Three patients had recurrent disease. One died of the primary disease and one died of other causes. Four are alive with no evidence of disease. Merging of actual study group with patients from recent literature resulted in 83 cases. The male vs. female ratio was 2:1, the most common location was the supraglottic region (52%) and the most predominant histological subtypes were adenoid cystic carcinoma (46%), mucoepidermoid carcinoma (35%) and adenocarcinoma NOS (12%). CONCLUSION: Laryngeal salivary gland carcinoma is a rare disease with a male predominance and most often localized in the supraglottic region. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. Recurrences are observed later than ten years after primary treatment and a long follow up time is advocated.

U2 - 10.1016/j.anl.2012.02.003

DO - 10.1016/j.anl.2012.02.003

M3 - Journal article

VL - 39

SP - 611

EP - 614

JO - Auris Nasus Larynx

JF - Auris Nasus Larynx

SN - 0385-8146

IS - 6

ER -