Rygnings og rygestopmidlers interaktion med lægemidler

Translated title of the contribution: Smoking cessation and drug interactions

Helle Karkov Lindberg Madsen*, Mette Gulløv, Ingeborg Farver-Vestergaard, Peter Hjorth, Lars Peter Nielsen, Anders Løkke Ottesen, Maija Bruun Haastrup

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Tobacco smoke can cause drug interactions by induction of CYP1A2, which metabolizes drugs like clozapine, olanzapine and theophylline. This means that smokers need higher doses to achieve the same plasma concentrations as non-smokers. Furthermore, smoking cessation can cause an increase in plasma concentrations of drugs metabolised by CYP1A2, which in turn may lead to adverse effects. Of the drugs used for smoking cessation only bupropione has clinically relevant interactions. All of these situations may be handled by dose adjustment.
Translated title of the contributionSmoking cessation and drug interactions
Original languageDanish
Article numberV02220117
JournalUgeskrift for Læger
Volume185
Issue number6
Pages (from-to)530-535
ISSN0041-5782
Publication statusPublished - 20. Mar 2023

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