Role of the cAMP Pathway in Glucose and Lipid Metabolism

Kim Ravnskjær, Anila Madiraju, Marc Montminy

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Abstract

3′–5′-Cyclic adenosine monophosphate (cyclic AMP or cAMP) was first described in 1957 as an intracellular second messenger mediating the effects of glucagon and epinephrine on hepatic glycogenolysis (Berthet et al., J Biol Chem 224(1):463–475, 1957). Since this initial characterization, cAMP has been firmly established as a versatile molecular signal involved in both central and peripheral regulation of energy homeostasis and nutrient partitioning. Many of these effects appear to be mediated at the transcriptional level, in part through the activation of the transcription factor CREB and its coactivators. Here we review current understanding of the mechanisms by which the cAMP signaling pathway triggers metabolic programs in insulin-responsive tissues
Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Number of pages21
PublisherSpringer
Publication date1. Jan 2016
Pages29-49
Chapter2
DOIs
Publication statusPublished - 1. Jan 2016
Externally publishedYes
SeriesHandbook of Experimental Pharmacology
ISSN0171-2004

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