Role of regenerative therapies on erectile dysfunction after radical prostatectomy

S. T. Hansen, M. Lund, L. D. Ostergaard, L. Lund*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The present study provides a review of stem cell therapy as a treatment of erectile dysfunction from peer-reviewed human and animal trials. A literature search was conducted in PubMed-Medline, Scopus, Embase, and Cochrane databases. Tweenty-three animal studies and seven human studies in the period from 1st of January 2000 to 1st of Mai 2020 were included. The seven included human studies are primary phase one trials, and most of them treat erectile dysfunction following radical prostatectomy by injection of stem cells into the corpus cavernosum. The primary outcome measure in all human trials is safety and secondary can stem cells play a role in the recovery of erectile function. All studies conclude that it is safe to use stem cells and the majority of the studies demonstrate an improvement in erectile function. The results from both animal and human trials are promising for stem cells as a restorative treatment, but data from large randomized human phase two trials is missing before it can be concluded, that stem cells is an effective treatment for erectile dysfunction in humans.

Original languageEnglish
JournalInternational Journal of Impotence Research
Volume33
Issue number4
Pages (from-to)488-496
ISSN0955-9930
DOIs
Publication statusPublished - May 2021

Keywords

  • Animals
  • Erectile Dysfunction/etiology
  • Humans
  • Male
  • Penile Erection
  • Penis
  • Prostate
  • Prostatectomy/adverse effects

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